Calcium in Cell-Extracellular Matrix Interactions

Sandeep Gopal, Hinke A B Multhaupt, John R Couchman

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    27 Citationer (Scopus)

    Abstract

    In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

    OriginalsprogEngelsk
    BogserieAdvances in Experimental Medicine and Biology
    Vol/bind1131
    Sider (fra-til)1079-1102
    Antal sider24
    ISSN0065-2598
    DOI
    StatusUdgivet - 2020

    Citationsformater