Carbohydrate-deficient transferrin--a valid marker of alcoholism in population studies? Results from the Copenhagen City Heart Study

M Grønbaek; U Becker; Jens Henrik Sahl Henriksen

Carbohydrate-deficient transferrin--a valid marker of alcoholism in population studies? Results from the Copenhagen City Heart Study

M Grønbaek, U Becker, Jens Henrik Sahl Henriksen

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

84 Citationer (Scopus)

Abstract

Udgivelsesdato: 1995-Apr

Originalsprog	Engelsk
Tidsskrift	Alcoholism: Clinical and Experimental Research
Vol/bind	19
Udgave nummer	2
Sider (fra-til)	457-61
Antal sider	4
ISSN	0145-6008
Status	Udgivet - 1995

Bibliografisk note

Keywords: Alcoholism; Biological Markers; Cross-Sectional Studies; Denmark; Female; Humans; Incidence; Male; Mass Screening; Predictive Value of Tests; Sampling Studies; Transferrin; Urban Population

Citationsformater

@article{66ab44802b8111df8ed1000ea68e967b,

title = "Carbohydrate-deficient transferrin--a valid marker of alcoholism in population studies? Results from the Copenhagen City Heart Study",

abstract = "Carbohydrate-deficient transferrin (CDT) was analyzed by a modified radioimmunoassay test in a random population sample of 400 individuals, and results were compared with reported alcohol intake derived from a structured questionnaire. Among the 180 men, the test was found to be acceptable with respect to detecting harmful alcohol intake (> 35 beverages/week) and alcohol intake above the recommended level (21 beverages/week), although the positive predictive values were low. Among the 220 women, the test was invalid with low predictive values. CDT was compared with other known markers of high alcohol intake, and it was observed that CDT had higher sensitivity and specificity than AST and short Michigan Alcoholism Screening Test (sMAST) in men, whereas the positive and negative predictive values were low in all tests. A combination of CDT and AST proved to be a better marker of both harmful alcohol intake and alcohol intake above the recommended level than the other markers. Neither CDT, AST, CDT/AST, nor sMAST proved to be useful as markers of alcohol intake in women. There were no differences between the values for pre- and postmenopausal women. These results from a population survey indicate that CDT is a marker of alcohol intake among men, although not ideal, but CDT cannot be used in the screening of harmful alcohol intake in women.",

author = "M Gr{\o}nbaek and U Becker and Henriksen, {Jens Henrik Sahl}",

note = "Keywords: Alcoholism; Biological Markers; Cross-Sectional Studies; Denmark; Female; Humans; Incidence; Male; Mass Screening; Predictive Value of Tests; Sampling Studies; Transferrin; Urban Population",

year = "1995",

language = "English",

volume = "19",

pages = "457--61",

journal = "Alcoholism: Clinical and Experimental Research",

issn = "0145-6008",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Carbohydrate-deficient transferrin--a valid marker of alcoholism in population studies? Results from the Copenhagen City Heart Study

AU - Grønbaek, M

AU - Becker, U

AU - Henriksen, Jens Henrik Sahl

N1 - Keywords: Alcoholism; Biological Markers; Cross-Sectional Studies; Denmark; Female; Humans; Incidence; Male; Mass Screening; Predictive Value of Tests; Sampling Studies; Transferrin; Urban Population

PY - 1995

Y1 - 1995

N2 - Carbohydrate-deficient transferrin (CDT) was analyzed by a modified radioimmunoassay test in a random population sample of 400 individuals, and results were compared with reported alcohol intake derived from a structured questionnaire. Among the 180 men, the test was found to be acceptable with respect to detecting harmful alcohol intake (> 35 beverages/week) and alcohol intake above the recommended level (21 beverages/week), although the positive predictive values were low. Among the 220 women, the test was invalid with low predictive values. CDT was compared with other known markers of high alcohol intake, and it was observed that CDT had higher sensitivity and specificity than AST and short Michigan Alcoholism Screening Test (sMAST) in men, whereas the positive and negative predictive values were low in all tests. A combination of CDT and AST proved to be a better marker of both harmful alcohol intake and alcohol intake above the recommended level than the other markers. Neither CDT, AST, CDT/AST, nor sMAST proved to be useful as markers of alcohol intake in women. There were no differences between the values for pre- and postmenopausal women. These results from a population survey indicate that CDT is a marker of alcohol intake among men, although not ideal, but CDT cannot be used in the screening of harmful alcohol intake in women.

AB - Carbohydrate-deficient transferrin (CDT) was analyzed by a modified radioimmunoassay test in a random population sample of 400 individuals, and results were compared with reported alcohol intake derived from a structured questionnaire. Among the 180 men, the test was found to be acceptable with respect to detecting harmful alcohol intake (> 35 beverages/week) and alcohol intake above the recommended level (21 beverages/week), although the positive predictive values were low. Among the 220 women, the test was invalid with low predictive values. CDT was compared with other known markers of high alcohol intake, and it was observed that CDT had higher sensitivity and specificity than AST and short Michigan Alcoholism Screening Test (sMAST) in men, whereas the positive and negative predictive values were low in all tests. A combination of CDT and AST proved to be a better marker of both harmful alcohol intake and alcohol intake above the recommended level than the other markers. Neither CDT, AST, CDT/AST, nor sMAST proved to be useful as markers of alcohol intake in women. There were no differences between the values for pre- and postmenopausal women. These results from a population survey indicate that CDT is a marker of alcohol intake among men, although not ideal, but CDT cannot be used in the screening of harmful alcohol intake in women.

M3 - Journal article

C2 - 7625582

VL - 19

SP - 457

EP - 461

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 2

ER -