TY - JOUR
T1 - Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function
AU - Friedrichsen, Martin
AU - Poulsen, Pernille
AU - Wojtaszewski, Jørgen
AU - Hansen, Peter Riis
AU - Vaag, Allan
AU - Rasmussen, Henrik Berg
N1 - OA
PY - 2013
Y1 - 2013
N2 - CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of mRNA expression. Here, we investigated mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of mRNA expression level in adipose tissue and the effect of gene duplication were assessed.
AB - CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of mRNA expression. Here, we investigated mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of mRNA expression level in adipose tissue and the effect of gene duplication were assessed.
U2 - 10.1371/journal.pone.0056861
DO - 10.1371/journal.pone.0056861
M3 - Journal article
C2 - 23468884
VL - 8
SP - e56861
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 2
ER -