Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis

Anne F Christensen; Hanne Lindegaard; Kim Hørslev-Petersen; Merete L Hetland; Bo Jannik Ejbjerg; Kristian Stengaard-Pedersen; Søren Jacobsen; Tine Lottenburger; Torkell Juulsgaad Ellingsen; Lis S Andersen; Ib Tønder Hansen; Henrik Skjødt; Jens K Pedersen; Ulrik Birk Lauridsen; Anders Svendsen; Ulrik Tarp; Jan Pødenphant; Mikkel Østergaard; Michael Peter Junker

doi:10.3899/jrheum.101241

Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis

Anne F Christensen, Hanne Lindegaard, Kim Hørslev-Petersen, Merete L Hetland, Bo Jannik Ejbjerg, Kristian Stengaard-Pedersen, Søren Jacobsen, Tine Lottenburger, Torkell Juulsgaad Ellingsen, Lis S Andersen, Ib Tønder Hansen, Henrik Skjødt, Jens K Pedersen, Ulrik Birk Lauridsen, Anders Svendsen, Ulrik Tarp, Jan Pødenphant, Mikkel Østergaard, Michael Peter Junker

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Cyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative rheumatoid arthritis (RA) have been suggested as 2 distinctive disease subsets with respect to disease activity and prognosis. Previously, we proposed that anti-CCP antibodies might have a chondrocyte-suppressive effect. We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings.

Originalsprog	Engelsk
Tidsskrift	Journal of Rheumatology
Vol/bind	38
Udgave nummer	8
Sider (fra-til)	1563-8
Antal sider	6
ISSN	0315-162X
DOI	https://doi.org/10.3899/jrheum.101241
Status	Udgivet - 2011

Adgang til dokumentet

10.3899/jrheum.101241

Citationsformater

Christensen, A. F., Lindegaard, H., Hørslev-Petersen, K., Hetland, M. L., Ejbjerg, B. J., Stengaard-Pedersen, K., Jacobsen, S., Lottenburger, T., Ellingsen, T. J., Andersen, L. S., Hansen, I. T., Skjødt, H., Pedersen, J. K., Lauridsen, U. B., Svendsen, A., Tarp, U., Pødenphant, J., Østergaard, M., & Junker, M. P. (2011). Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. Journal of Rheumatology, 38(8), 1563-8. https://doi.org/10.3899/jrheum.101241

Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. / Christensen, Anne F; Lindegaard, Hanne; Hørslev-Petersen, Kim et al.
I: Journal of Rheumatology, Bind 38, Nr. 8, 2011, s. 1563-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Christensen, AF, Lindegaard, H, Hørslev-Petersen, K, Hetland, ML, Ejbjerg, BJ, Stengaard-Pedersen, K, Jacobsen, S, Lottenburger, T, Ellingsen, TJ, Andersen, LS, Hansen, IT, Skjødt, H, Pedersen, JK, Lauridsen, UB, Svendsen, A, Tarp, U, Pødenphant, J, Østergaard, M & Junker, MP 2011, 'Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis', Journal of Rheumatology, bind 38, nr. 8, s. 1563-8. https://doi.org/10.3899/jrheum.101241

Christensen AF, Lindegaard H, Hørslev-Petersen K, Hetland ML, Ejbjerg BJ, Stengaard-Pedersen K et al. Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. Journal of Rheumatology. 2011;38(8):1563-8. doi: 10.3899/jrheum.101241

Christensen, Anne F ; Lindegaard, Hanne ; Hørslev-Petersen, Kim et al. / Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. I: Journal of Rheumatology. 2011 ; Bind 38, Nr. 8. s. 1563-8.

@article{0c9b7f6af70c454abe55ec28fb546362,

title = "Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis",

abstract = "Cyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative rheumatoid arthritis (RA) have been suggested as 2 distinctive disease subsets with respect to disease activity and prognosis. Previously, we proposed that anti-CCP antibodies might have a chondrocyte-suppressive effect. We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings.",

author = "Christensen, {Anne F} and Hanne Lindegaard and Kim H{\o}rslev-Petersen and Hetland, {Merete L} and Ejbjerg, {Bo Jannik} and Kristian Stengaard-Pedersen and S{\o}ren Jacobsen and Tine Lottenburger and Ellingsen, {Torkell Juulsgaad} and Andersen, {Lis S} and Hansen, {Ib T{\o}nder} and Henrik Skj{\o}dt and Pedersen, {Jens K} and Lauridsen, {Ulrik Birk} and Anders Svendsen and Ulrik Tarp and Jan P{\o}denphant and Mikkel {\O}stergaard and Junker, {Michael Peter}",

year = "2011",

doi = "10.3899/jrheum.101241",

language = "English",

volume = "38",

pages = "1563--8",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology Publishing Co. Ltd.",

number = "8",

}

TY - JOUR

T1 - Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis

AU - Christensen, Anne F

AU - Lindegaard, Hanne

AU - Hørslev-Petersen, Kim

AU - Hetland, Merete L

AU - Ejbjerg, Bo Jannik

AU - Stengaard-Pedersen, Kristian

AU - Jacobsen, Søren

AU - Lottenburger, Tine

AU - Ellingsen, Torkell Juulsgaad

AU - Andersen, Lis S

AU - Hansen, Ib Tønder

AU - Skjødt, Henrik

AU - Pedersen, Jens K

AU - Lauridsen, Ulrik Birk

AU - Svendsen, Anders

AU - Tarp, Ulrik

AU - Pødenphant, Jan

AU - Østergaard, Mikkel

AU - Junker, Michael Peter

PY - 2011

Y1 - 2011

N2 - Cyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative rheumatoid arthritis (RA) have been suggested as 2 distinctive disease subsets with respect to disease activity and prognosis. Previously, we proposed that anti-CCP antibodies might have a chondrocyte-suppressive effect. We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings.

AB - Cyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative rheumatoid arthritis (RA) have been suggested as 2 distinctive disease subsets with respect to disease activity and prognosis. Previously, we proposed that anti-CCP antibodies might have a chondrocyte-suppressive effect. We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings.

U2 - 10.3899/jrheum.101241

DO - 10.3899/jrheum.101241

M3 - Journal article

SN - 0315-162X

VL - 38

SP - 1563

EP - 1568

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 8

ER -