Case-fatality of COPD exacerbations: a meta-analysis and statistical modeling approach

M Hoogendoorn; R T Hoogenveen; M P Rutten-van Mölken; J Vestbo; T L Feenstra

doi:10.1183/09031936.00043710

Case-fatality of COPD exacerbations: a meta-analysis and statistical modeling approach

M Hoogendoorn, R T Hoogenveen, M P Rutten-van Mölken, J Vestbo, T L Feenstra

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

177 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Jul-1

Originalsprog	Engelsk
Tidsskrift	European Respiratory Journal
Vol/bind	37
Udgave nummer	3
Sider (fra-til)	508-515
Antal sider	8
ISSN	0903-1936
DOI	https://doi.org/10.1183/09031936.00043710
Status	Udgivet - 2010

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Citationsformater

@article{14b289f183a54385ba097d50094cc9f0,

title = "Case-fatality of COPD exacerbations: a meta-analysis and statistical modeling approach",

abstract = "Objective of the study was to estimate the case-fatality of a severe exacerbation from long-term survival data presented in the literature. A literature search identified studies reporting at least 1.5 year survival after a severe COPD exacerbation resulting in hospitalization. Each study's survival curve was divided into a critical and a stable period. Mortality during the stable period was then estimated by extrapolating the survival curve during the stable period back to the time of exacerbation onset. Case-fatality was defined as the excess mortality that results from an exacerbation and was calculated as 1 minus the (backwardly) extrapolated survival during the stable period at the time of exacerbation onset. The 95% confidence intervals of the estimated case-fatalities were obtained by bootstrapping. A random effect model was used to combine all estimates into a weighted average with 95%-confidence interval. The meta-analysis based on six studies that fulfilled the inclusion criteria resulted in a weighted average case-fatality rate of 15.6% (95%CI:10.9%-20.3%), ranging from 11.4% to 19.0% for the individual studies. A severe COPD exacerbation requiring hospitalization not only results in higher mortality risks during hospitalization, but also in the time period after discharge and contributes substantially to total COPD mortality.",

author = "M Hoogendoorn and Hoogenveen, {R T} and {Rutten-van M{\"o}lken}, {M P} and J Vestbo and Feenstra, {T L}",

year = "2010",

doi = "10.1183/09031936.00043710",

language = "English",

volume = "37",

pages = "508--515",

journal = "European Respiratory Journal",

issn = "0903-1936",

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TY - JOUR

T1 - Case-fatality of COPD exacerbations: a meta-analysis and statistical modeling approach

AU - Hoogendoorn, M

AU - Hoogenveen, R T

AU - Rutten-van Mölken, M P

AU - Vestbo, J

AU - Feenstra, T L

PY - 2010

Y1 - 2010

N2 - Objective of the study was to estimate the case-fatality of a severe exacerbation from long-term survival data presented in the literature. A literature search identified studies reporting at least 1.5 year survival after a severe COPD exacerbation resulting in hospitalization. Each study's survival curve was divided into a critical and a stable period. Mortality during the stable period was then estimated by extrapolating the survival curve during the stable period back to the time of exacerbation onset. Case-fatality was defined as the excess mortality that results from an exacerbation and was calculated as 1 minus the (backwardly) extrapolated survival during the stable period at the time of exacerbation onset. The 95% confidence intervals of the estimated case-fatalities were obtained by bootstrapping. A random effect model was used to combine all estimates into a weighted average with 95%-confidence interval. The meta-analysis based on six studies that fulfilled the inclusion criteria resulted in a weighted average case-fatality rate of 15.6% (95%CI:10.9%-20.3%), ranging from 11.4% to 19.0% for the individual studies. A severe COPD exacerbation requiring hospitalization not only results in higher mortality risks during hospitalization, but also in the time period after discharge and contributes substantially to total COPD mortality.

AB - Objective of the study was to estimate the case-fatality of a severe exacerbation from long-term survival data presented in the literature. A literature search identified studies reporting at least 1.5 year survival after a severe COPD exacerbation resulting in hospitalization. Each study's survival curve was divided into a critical and a stable period. Mortality during the stable period was then estimated by extrapolating the survival curve during the stable period back to the time of exacerbation onset. Case-fatality was defined as the excess mortality that results from an exacerbation and was calculated as 1 minus the (backwardly) extrapolated survival during the stable period at the time of exacerbation onset. The 95% confidence intervals of the estimated case-fatalities were obtained by bootstrapping. A random effect model was used to combine all estimates into a weighted average with 95%-confidence interval. The meta-analysis based on six studies that fulfilled the inclusion criteria resulted in a weighted average case-fatality rate of 15.6% (95%CI:10.9%-20.3%), ranging from 11.4% to 19.0% for the individual studies. A severe COPD exacerbation requiring hospitalization not only results in higher mortality risks during hospitalization, but also in the time period after discharge and contributes substantially to total COPD mortality.

U2 - 10.1183/09031936.00043710

DO - 10.1183/09031936.00043710

M3 - Journal article

SN - 0903-1936

VL - 37

SP - 508

EP - 515

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 3

ER -