CD4 T cell activation and disease activity at onset of multiple sclerosis.

J Jensen, Annika Reynberg Langkilde, C Fenst, M. S. Nicolaisen, H. G. Roed, M Christensen, F Sellebjerg

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    Abstract

    We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients
    OriginalsprogEngelsk
    TidsskriftJournal of Neuroimmunology
    Vol/bind149
    Udgave nummer1-2
    Sider (fra-til)202-209
    ISSN0165-5728
    StatusUdgivet - 2004

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