@article{b1f8aad0a07311dd86a6000ea68e967b,
title = "Cell-mediated immune responses to Plasmodium falciparum purified soluble antigens in sickle-cell trait subjects",
abstract = "To determine the possible differences in the immune response to Plasmodium falciparum between sickle-cell trait (Hb AS) and normal haemoglobin (Hb AA) individuals, we examined 35 Hb AS and 24 Hb AA subjects matched for age and microenvironment. Their age was 2-55 years and all lived in a malaria endemic area 300 km south of Khartoum. Antibodies to ring-infected erythrocyte surface antigen (Pf155/RESA) and to circumsporozoite (CS) protein (anti-NANP40) indicated equal exposure to falciparum malaria. Peripheral blood mononuclear cells (BMNCs) from 20/35 (57%) Hb AS subjects compared with 10/24 (42%) Hb AA subjects, responded to affinity-purified P. falciparum soluble antigens (SPAg). Of those responding to SPAg, 9 (26%) Hb AS subjects and only two (8%) Hb AA subjects had high responses. The mean proliferative response to SPAg of BMNCs from Hb AS individuals was significantly higher than in Hb AA individuals (P less than 0.025). Responses of BMNCs to PPD and PHA were also higher among Hb AS individuals and correlated positively with responses to SPAg. These findings support the hypotheses that the sickle-cell trait protects individuals from P. falciparum infections, at least in part, by modulating the immune response.",
author = "Bayoumi, {R A} and Abu-Zeid, {Y A} and Abdulhadi, {N H} and Saeed, {B O} and Theander, {T G} and L Hviid and Ghalib, {H W} and Nugud, {A H} and S Jepsen and Jensen, {J B}",
note = "Keywords: Adolescent; Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Child; Child, Preschool; Humans; Immunity, Cellular; Leukocytes, Mononuclear; Lymphocyte Activation; Middle Aged; Phytohemagglutinins; Plasmodium falciparum; Protozoan Proteins; Sickle Cell Trait; Sudan; Tuberculin",
year = "1990",
language = "English",
volume = "25",
pages = "243--9",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1-3",
}