TY - JOUR
T1 - Cell survival and multiplication. The overriding need for signals: from unicellular to multicellular systems
AU - Rasmussen, L
AU - Christensen, Søren Tvorup
AU - Schousboe, P
AU - Wheatley, D N
N1 - Keywords: Animals; Cell Division; Enzyme Inhibitors; Escherichia coli; Guanylate Cyclase; Protein Kinase C; Saccharomyces cerevisiae; Signal Transduction; Tetrahymena thermophila
PY - 1996
Y1 - 1996
N2 - There are clear similarities in the control mechanisms for cell survival and multiplication in the two eukaryotes, the ciliate Tetrahymena thermophila and the yeast, Saccharomyces cerevisiae. Cell multiplication in both organisms is activated by the same compounds (phorbol esters, diacylglycerol, tetrapyrroles, etc.). These compounds also affect cell multiplication and other activities in mammalian cell systems. This homology in control mechanisms in two distinct groups of unicellular eukaryotes on the one hand, and in cells from multicellular animals on the other, leads us to propose that these cytoplasmic control mechanisms for cell survival and multiplication originated in the unicellular eukaryotes.
AB - There are clear similarities in the control mechanisms for cell survival and multiplication in the two eukaryotes, the ciliate Tetrahymena thermophila and the yeast, Saccharomyces cerevisiae. Cell multiplication in both organisms is activated by the same compounds (phorbol esters, diacylglycerol, tetrapyrroles, etc.). These compounds also affect cell multiplication and other activities in mammalian cell systems. This homology in control mechanisms in two distinct groups of unicellular eukaryotes on the one hand, and in cells from multicellular animals on the other, leads us to propose that these cytoplasmic control mechanisms for cell survival and multiplication originated in the unicellular eukaryotes.
M3 - Journal article
C2 - 8998973
SN - 0378-1097
VL - 137
SP - 123
EP - 128
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2-3
ER -