Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

Morten Blinkenberg; Henrik K Mathiesen; Thomas Tscherning; Agnete Jønsson; Claus Svarer; Søren Holm; Finn Sellebjerg; Olaf B Paulson; Lars G Hanson; Per S Sorensen

doi:10.1179/1743132811Y.0000000059

Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

Morten Blinkenberg, Henrik K Mathiesen, Thomas Tscherning, Agnete Jønsson, Claus Svarer, Søren Holm, Finn Sellebjerg, Olaf B Paulson, Lars G Hanson, Per S Sorensen

IKM

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.

Originalsprog	Engelsk
Tidsskrift	Neurological Research
Vol/bind	34
Udgave nummer	1
Sider (fra-til)	52-8
Antal sider	7
ISSN	0161-6412
DOI	https://doi.org/10.1179/1743132811Y.0000000059
Status	Udgivet - jan. 2012

Adgang til dokumentet

10.1179/1743132811Y.0000000059

Citationsformater

Blinkenberg, M., Mathiesen, H. K., Tscherning, T., Jønsson, A., Svarer, C., Holm, S., Sellebjerg, F., Paulson, O. B., Hanson, L. G., & Sorensen, P. S. (2012). Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurological Research, 34(1), 52-8. https://doi.org/10.1179/1743132811Y.0000000059

Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis : an exploratory study. / Blinkenberg, Morten; Mathiesen, Henrik K; Tscherning, Thomas; Jønsson, Agnete; Svarer, Claus; Holm, Søren; Sellebjerg, Finn ; Paulson, Olaf B; Hanson, Lars G; Sorensen, Per S.

I: Neurological Research, Bind 34, Nr. 1, 01.2012, s. 52-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Blinkenberg, Morten ; Mathiesen, Henrik K ; Tscherning, Thomas ; Jønsson, Agnete ; Svarer, Claus ; Holm, Søren ; Sellebjerg, Finn ; Paulson, Olaf B ; Hanson, Lars G ; Sorensen, Per S. / Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis : an exploratory study. I: Neurological Research. 2012 ; Bind 34, Nr. 1. s. 52-8.

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abstract = "Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.",

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AU - Blinkenberg, Morten

AU - Mathiesen, Henrik K

AU - Tscherning, Thomas

AU - Jønsson, Agnete

AU - Svarer, Claus

AU - Holm, Søren

AU - Sellebjerg, Finn

AU - Paulson, Olaf B

AU - Hanson, Lars G

AU - Sorensen, Per S

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AB - Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.

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DO - 10.1179/1743132811Y.0000000059

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JF - Neurological Research

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