Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

Ronan Mg Berg; Sarah Taudorf; Damian M Bailey; Carsten Lundby; Fin Stolze Larsen; Bente Klarlund Pedersen; Kirsten Møller; Kirsten Møller

doi:10.1186/cc8873

Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

Ronan Mg Berg, Sarah Taudorf, Damian M Bailey, Carsten Lundby, Fin Stolze Larsen, Bente Klarlund Pedersen, Kirsten Møller, Kirsten Møller

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

34 Citationer (Scopus)

Abstract

Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

Originalsprog	Engelsk
Tidsskrift	Critical Care
Vol/bind	14
Udgave nummer	1
Sider (fra-til)	R16
ISSN	1574-4280
DOI	https://doi.org/10.1186/cc8873
Status	Udgivet - 1 jan. 2010

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abstract = "Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.",

author = "Berg, {Ronan Mg} and Sarah Taudorf and Bailey, {Damian M} and Carsten Lundby and Larsen, {Fin Stolze} and Pedersen, {Bente Klarlund} and Kirsten M{\o}ller and Kirsten M{\o}ller",

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AU - Berg, Ronan Mg

AU - Taudorf, Sarah

AU - Bailey, Damian M

AU - Lundby, Carsten

AU - Larsen, Fin Stolze

AU - Pedersen, Bente Klarlund

AU - Møller, Kirsten

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N2 - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

AB - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

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DO - 10.1186/cc8873

M3 - Journal article

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