Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance

Jannik Stokholm*, Lars Kristian Hebsgaard Birkmose, Abd Al Bari Omar Ahmed, Claudio Csillag, Troels Wesenberg Kjær, Thomas Christensen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

6 Citationer (Scopus)

Abstract

Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLRdil.vel.). The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1 days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measurements of SCL and PLRdil.vel up to twice daily. SCL and PLRdil.vel. during delirium were lower than without delirium present. For SCL the unadjusted difference was −40.8% (95% CI (−55.1 to −22.0), P value <.001) and for PLRdil.vel the unadjusted difference was −0.22 mm/s (95% CI (−0.42 to −0.01), P value = .041). The results demonstrate changes in sympathetic autonomic nervous system regulation during delirium in acute stroke patients.

OriginalsprogEngelsk
Artikelnummer117582
TidsskriftJournal of the Neurological Sciences
Vol/bind428
Antal sider9
ISSN0022-510X
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
Aase og Ejnar Danielsens Fond (grant ID 10-002009), A & J C Tvergaards Fond (no grant ID), Carl og Ellen Hertz? Legat til Dansk L?ge-og Naturvidenskab (grant ID 7179-2), Fabrikant Karl G Andersens (Andersons) Fond (grant ID 9292), Familien Hede Nielsens Fond (grant ID 2017-0821), Fru Olga Bryde Nielsens Fond (no grant ID), Helen Rudes Fond (two grants, one with grant ID 60988 and one without a grant ID), Jascha Fonden (grant ID 6195), Kaptajnl?jtnant Harald Jensens og Hustrus Fond (no grant ID), L?ge Ingrid Munkholms Legat (no grant ID), L?geforeningens Forskningsfond (H?jmosegaard Legatet) (grant ID 2017-1064/79), Research Grant from Nordsj?llands Hospital (no grant ID), Toyota-Fonden (grant ID KJ/BG-9178F).

Funding Information:
Aase og Ejnar Danielsens Fond (grant ID 10-002009 ), A & J C Tvergaards Fond (no grant ID), Carl og Ellen Hertz’ Legat til Dansk Læge-og Naturvidenskab (grant ID 7179-2 ), Fabrikant Karl G Andersens (Andersons) Fond (grant ID 9292 ), Familien Hede Nielsens Fond (grant ID 2017-0821 ), Fru Olga Bryde Nielsens Fond (no grant ID), Helen Rudes Fond (two grants, one with grant ID 60988 and one without a grant ID), Jascha Fonden (grant ID 6195 ), Kaptajnløjtnant Harald Jensens og Hustrus Fond (no grant ID), Læge Ingrid Munkholms Legat (no grant ID), Lægeforeningens Forskningsfond (Højmosegaard Legatet) (grant ID 2017-1064/79 ), Research Grant from Nordsjællands Hospital (no grant ID), Toyota-Fonden (grant ID KJ/BG-9178F ).

Publisher Copyright:
© 2021 Elsevier B.V.

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