Characteristics and drivers of fatigue in patients with psoriasis and psoriatic arthritis: A cross sectional study

Lea Nymand, Lars Erik Kristensen, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1 Citationer (Scopus)
2 Downloads (Pure)

Abstract

Background: A multitude of factors may influence fatigue in psoriasis and psoriatic arthritis (PsA); however, their individual fatigue components have not been thoroughly examined. Objectives: To explore characteristics of fatigue and its potential drivers in a cohort of patients with psoriasis with or without PsA. Methods: Adults with psoriasis and a nonpsoriasis control group completed the Multidimensional Fatigue Inventory-20 questionnaire. Patients with psoriasis also reported joint pain intensity, pruritus, skin pain, and sleep problems using a numerical rating scale. Linear regression models were applied to continuous outcomes, and beta coefficients (β) for the slopes were estimated with 95% confidence intervals (CIs). Results: Among 2741 adults with psoriasis (of which 593 also had PsA) and 3788 controls, the impact on total fatigue was greatest for PsA (β = 5.22; 95% CI, 3.55-6.90), followed by psoriasis (β = 2.10; 95% CI, 0.96-3.25), compared with the general population (Ptrend <.0001). Among patients with psoriasis with or without PsA, increasing joint pain intensity was associated with overall fatigue (β = 2.23 [95% CI, 2.03-2.44] for each 1-point increase in joint pain numerical rating scale score). Limitations: We lacked information on the effect of pharmacotherapy. Conclusions: These findings highlight the importance of a symptom-based approach when treating psoriasis, rather than focusing on objective severity measures alone.

OriginalsprogEngelsk
TidsskriftJournal of the American Academy of Dermatology
Vol/bind91
Udgave nummer1
Sider (fra-til)57-63
Antal sider7
ISSN0190-9622
DOI
StatusUdgivet - 2024

Bibliografisk note

Publisher Copyright:
© 2024 American Academy of Dermatology, Inc.

Citationsformater