Characterization of cardiac repolarization in the Göttingen minipig

Morten Laursen; Søren-Peter Olesen; Morten Grunnet; Tomas Mow; Thomas Jespersen; Thomas Jespersen

doi:10.1016/j.vascn.2010.10.001

Characterization of cardiac repolarization in the Göttingen minipig

Morten Laursen, Søren-Peter Olesen, Morten Grunnet, Tomas Mow, Thomas Jespersen, Thomas Jespersen

Physiology of circulation, kidney and lung

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

26 Citationer (Scopus)

Abstract

The minipig represents an attractive experimental animal within cardiovascular research due to its extensive similarities to the human heart in terms of anatomy and physiology. Although minipigs have been used for cardiovascular research for decades no thorough characterization of the minipig cardiac electrophysiology has been performed. Therefore, we have for the first time characterized the minipig cardiac repolarization in a series of experiments ranging from mRNA quantification to in vivo studies.

Originalsprog	Engelsk
Tidsskrift	Journal of Pharmacological and Toxicological Methods
Vol/bind	63
Udgave nummer	2
Sider (fra-til)	186-95
Antal sider	10
ISSN	1056-8719
DOI	https://doi.org/10.1016/j.vascn.2010.10.001
Status	Udgivet - 2011

Adgang til dokumentet

10.1016/j.vascn.2010.10.001

Citationsformater

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AU - Laursen, Morten

AU - Olesen, Søren-Peter

AU - Grunnet, Morten

AU - Mow, Tomas

AU - Jespersen, Thomas

PY - 2011

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AB - The minipig represents an attractive experimental animal within cardiovascular research due to its extensive similarities to the human heart in terms of anatomy and physiology. Although minipigs have been used for cardiovascular research for decades no thorough characterization of the minipig cardiac electrophysiology has been performed. Therefore, we have for the first time characterized the minipig cardiac repolarization in a series of experiments ranging from mRNA quantification to in vivo studies.

U2 - 10.1016/j.vascn.2010.10.001

DO - 10.1016/j.vascn.2010.10.001

M3 - Journal article

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JO - Journal of Pharmacological and Toxicological Methods

JF - Journal of Pharmacological and Toxicological Methods

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