Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

Astrid Plamboeck; Simon Veedfald; Carolyn Deacon; Bolette Hartmann; Andre Wettergren; Lars Bo Svendsen; Søren Meisner; Claus Hovendal; Filip Krag Knop; Tina Vilsbøll; Jens Juul Holst

doi:10.1530/EJE-13-0264

Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

Astrid Plamboeck, Simon Veedfald, Carolyn Deacon, Bolette Hartmann, Andre Wettergren, Lars Bo Svendsen, Søren Meisner, Claus Hovendal, Filip Krag Knop, Tina Vilsbøll, Jens Juul Holst

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

51 Citationer (Scopus)

Abstract

OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	169
Sider (fra-til)	187-201
Antal sider	14
ISSN	0804-4643
DOI	https://doi.org/10.1530/EJE-13-0264
Status	Udgivet - 23 maj 2013

Adgang til dokumentet

10.1530/EJE-13-0264

Citationsformater

Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon ; Deacon, Carolyn ; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendal, Claus; Knop, Filip Krag ; Vilsbøll, Tina ; Holst, Jens Juul.

I: European Journal of Endocrinology, Bind 169, 23.05.2013, s. 187-201.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Plamboeck, Astrid ; Veedfald, Simon ; Deacon, Carolyn ; Hartmann, Bolette ; Wettergren, Andre ; Svendsen, Lars Bo ; Meisner, Søren ; Hovendal, Claus ; Knop, Filip Krag ; Vilsbøll, Tina ; Holst, Jens Juul. / Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty. I: European Journal of Endocrinology. 2013 ; Bind 169. s. 187-201.

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title = "Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty",

abstract = "OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P",

author = "Astrid Plamboeck and Simon Veedfald and Carolyn Deacon and Bolette Hartmann and Andre Wettergren and Svendsen, {Lars Bo} and S{\o}ren Meisner and Claus Hovendal and Knop, {Filip Krag} and Tina Vilsb{\o}ll and Holst, {Jens Juul}",

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doi = "10.1530/EJE-13-0264",

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T1 - Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

AU - Plamboeck, Astrid

AU - Veedfald, Simon

AU - Deacon, Carolyn

AU - Hartmann, Bolette

AU - Wettergren, Andre

AU - Svendsen, Lars Bo

AU - Meisner, Søren

AU - Hovendal, Claus

AU - Knop, Filip Krag

AU - Vilsbøll, Tina

AU - Holst, Jens Juul

PY - 2013/5/23

Y1 - 2013/5/23

N2 - OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P

AB - OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P

U2 - 10.1530/EJE-13-0264

DO - 10.1530/EJE-13-0264

M3 - Journal article

C2 - 23704713

VL - 169

SP - 187

EP - 201

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

ER -