Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Contact Dermatitis |
| Vol/bind | 61 |
| Udgave nummer | 1 |
| Sider (fra-til) | 22-30 |
| Antal sider | 9 |
| ISSN | 0105-1873 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Case-Control Studies; Denmark; Dermatitis, Allergic Contact; Dermatitis, Atopic; Female; Humans; Leg Ulcer; Logistic Models; Male; Matched-Pair Analysis; Middle Aged; Multiple Chemical Sensitivity; Multivariate Analysis; Risk FactorsAdgang til dokumentet
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I: Contact Dermatitis, Bind 61, Nr. 1, 2009, s. 22-30.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Characterization of the polysensitized patient: a matched case-control study
AU - Carlsen, Berit Christina
AU - Andersen, Klaus Ejner
AU - Menné, Torkil
AU - Johansen, Jeanne Duus
N1 - Keywords: Case-Control Studies; Denmark; Dermatitis, Allergic Contact; Dermatitis, Atopic; Female; Humans; Leg Ulcer; Logistic Models; Male; Matched-Pair Analysis; Middle Aged; Multiple Chemical Sensitivity; Multivariate Analysis; Risk Factors
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Polysensitization ( >or= 3 contact allergies) may be regarded as a special entity in patients with contact allergies. However, this group of polysensitized patients is poorly characterized. Filaggrin mutations are associated with atopic eczema and lead to impaired skin barrier which may predispose to contact allergy. Therefore, it is of interest to consider atopic eczema and contact allergies, especially in patients with multiple allergies. OBJECTIVE: To characterize polysensitized patients regarding occurrence, duration and course of dermatitis, and examine potential risk factors for polysensitization, including atopic eczema. METHODS: A questionnaire case-control study of 562 polysensitized and 1124 single/double-sensitized individuals was performed. RESULTS: The results show that 45% of polysensitized and 31% of single/double-sensitized patients had or had had atopic eczema, and atopic eczema was identified as a risk factor for polysensitization. Patients with leg ulcer constituted only a minor part of the polysensitized group and leg ulcers were not identified as a risk factor for polysensitization in this study. The influence of contact allergies on duration and course of disease diverged between the group of patients with atopic eczema and the group without atopic eczema. CONCLUSION: Patients with atopic eczema were overrepresented in the group of polysensitized patients and polysensitized patients should be viewed in the light of occurrence or lack of atopic eczema.
AB - BACKGROUND: Polysensitization ( >or= 3 contact allergies) may be regarded as a special entity in patients with contact allergies. However, this group of polysensitized patients is poorly characterized. Filaggrin mutations are associated with atopic eczema and lead to impaired skin barrier which may predispose to contact allergy. Therefore, it is of interest to consider atopic eczema and contact allergies, especially in patients with multiple allergies. OBJECTIVE: To characterize polysensitized patients regarding occurrence, duration and course of dermatitis, and examine potential risk factors for polysensitization, including atopic eczema. METHODS: A questionnaire case-control study of 562 polysensitized and 1124 single/double-sensitized individuals was performed. RESULTS: The results show that 45% of polysensitized and 31% of single/double-sensitized patients had or had had atopic eczema, and atopic eczema was identified as a risk factor for polysensitization. Patients with leg ulcer constituted only a minor part of the polysensitized group and leg ulcers were not identified as a risk factor for polysensitization in this study. The influence of contact allergies on duration and course of disease diverged between the group of patients with atopic eczema and the group without atopic eczema. CONCLUSION: Patients with atopic eczema were overrepresented in the group of polysensitized patients and polysensitized patients should be viewed in the light of occurrence or lack of atopic eczema.
U2 - 10.1111/j.1600-0536.2009.01573.x
DO - 10.1111/j.1600-0536.2009.01573.x
M3 - Journal article
C2 - 19659961
SN - 0105-1873
VL - 61
SP - 22
EP - 30
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 1
ER -