Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers

Britt W. Jensen; Julie Aarestrup; Kim Blond; Marit E. Jorgensen; Andrew G. Renehan; Dorte Vistisen; Jennifer L. Baker

doi:10.1093/jnci/djac192

Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers

Britt W. Jensen^*, Julie Aarestrup, Kim Blond, Marit E. Jorgensen, Andrew G. Renehan, Dorte Vistisen, Jennifer L. Baker

^*Corresponding author af dette arbejde

Biostatistisk afdeling

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Abstract

Elevated childhood body mass index (BMI), commonly examined as a “once-only” value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations

Originalsprog	Engelsk
Tidsskrift	National Cancer Institute. Journal (Online)
Vol/bind	115
Udgave nummer	1
Sider (fra-til)	43-51
Antal sider	9
ISSN	0027-8874
DOI	https://doi.org/10.1093/jnci/djac192
Status	Udgivet - 2023

Adgang til dokumentet

10.1093/jnci/djac192

https://pmc.ncbi.nlm.nih.gov/articles/PMC9830482/pdf/djac192.pdfLicens: Andet

Citationsformater

@article{69d5273a706d4900b9c3ae878a86e40a,

title = "Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers",

abstract = "Background Elevated childhood body mass index (BMI), commonly examined as a {"}once-only{"} value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations. Methods Five sex-specific latent class BMI trajectories were generated for 301 927 children (149 325 girls) aged 6-15 years from the Copenhagen School Health Records Register. Information on obesity-related cancers and T2D was obtained from national health registers. Incidence rate ratios (IRR), cumulative incidences, and confidence intervals (CI) were estimated using Poisson regressions. Results Compared with the average childhood BMI trajectory (containing approximately 40% of individuals), the rate of obesity-related cancer (excluding breast cancer) increased with higher childhood BMI trajectories among women. The highest rates occurred in the overweight (IRR = 1.27, 95% CI = 1.17 to 1.38) and obesity (IRR = 1.79, 95% CI = 1.53 to 2.08) BMI trajectories. Similar patterns were observed among men. In contrast, women with the obesity childhood BMI trajectory had the lowest rate of pre- and postmenopausal breast cancer (IRR = 0.59, 95% CI = 0.43 to 0.80, and IRR = 0.41, 95% CI = 0.30 to 0.57, respectively). For all trajectories, the cumulative risk of obesity-related cancer increased with adult-onset T2D. Conclusion Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D conferred additional risk for obesity-related cancer, but the effect did not differ across childhood BMI trajectories.",

keywords = "BREAST-CANCER, COLORECTAL-CANCER, UNITED-STATES, RISK, LIFE, FATNESS, TRENDS, SHAPE",

author = "Jensen, {Britt W.} and Julie Aarestrup and Kim Blond and Jorgensen, {Marit E.} and Renehan, {Andrew G.} and Dorte Vistisen and Baker, {Jennifer L.}",

year = "2023",

doi = "10.1093/jnci/djac192",

language = "English",

volume = "115",

pages = "43--51",

journal = "National Cancer Institute. Journal (Online)",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers

AU - Jensen, Britt W.

AU - Aarestrup, Julie

AU - Blond, Kim

AU - Jorgensen, Marit E.

AU - Renehan, Andrew G.

AU - Vistisen, Dorte

AU - Baker, Jennifer L.

PY - 2023

Y1 - 2023

N2 - Background Elevated childhood body mass index (BMI), commonly examined as a "once-only" value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations. Methods Five sex-specific latent class BMI trajectories were generated for 301 927 children (149 325 girls) aged 6-15 years from the Copenhagen School Health Records Register. Information on obesity-related cancers and T2D was obtained from national health registers. Incidence rate ratios (IRR), cumulative incidences, and confidence intervals (CI) were estimated using Poisson regressions. Results Compared with the average childhood BMI trajectory (containing approximately 40% of individuals), the rate of obesity-related cancer (excluding breast cancer) increased with higher childhood BMI trajectories among women. The highest rates occurred in the overweight (IRR = 1.27, 95% CI = 1.17 to 1.38) and obesity (IRR = 1.79, 95% CI = 1.53 to 2.08) BMI trajectories. Similar patterns were observed among men. In contrast, women with the obesity childhood BMI trajectory had the lowest rate of pre- and postmenopausal breast cancer (IRR = 0.59, 95% CI = 0.43 to 0.80, and IRR = 0.41, 95% CI = 0.30 to 0.57, respectively). For all trajectories, the cumulative risk of obesity-related cancer increased with adult-onset T2D. Conclusion Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D conferred additional risk for obesity-related cancer, but the effect did not differ across childhood BMI trajectories.

AB - Background Elevated childhood body mass index (BMI), commonly examined as a "once-only" value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations. Methods Five sex-specific latent class BMI trajectories were generated for 301 927 children (149 325 girls) aged 6-15 years from the Copenhagen School Health Records Register. Information on obesity-related cancers and T2D was obtained from national health registers. Incidence rate ratios (IRR), cumulative incidences, and confidence intervals (CI) were estimated using Poisson regressions. Results Compared with the average childhood BMI trajectory (containing approximately 40% of individuals), the rate of obesity-related cancer (excluding breast cancer) increased with higher childhood BMI trajectories among women. The highest rates occurred in the overweight (IRR = 1.27, 95% CI = 1.17 to 1.38) and obesity (IRR = 1.79, 95% CI = 1.53 to 2.08) BMI trajectories. Similar patterns were observed among men. In contrast, women with the obesity childhood BMI trajectory had the lowest rate of pre- and postmenopausal breast cancer (IRR = 0.59, 95% CI = 0.43 to 0.80, and IRR = 0.41, 95% CI = 0.30 to 0.57, respectively). For all trajectories, the cumulative risk of obesity-related cancer increased with adult-onset T2D. Conclusion Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D conferred additional risk for obesity-related cancer, but the effect did not differ across childhood BMI trajectories.

KW - BREAST-CANCER

KW - COLORECTAL-CANCER

KW - UNITED-STATES

KW - RISK

KW - LIFE

KW - FATNESS

KW - TRENDS

KW - SHAPE

U2 - 10.1093/jnci/djac192

DO - 10.1093/jnci/djac192

M3 - Journal article

C2 - 36214627

SN - 0027-8874

VL - 115

SP - 43

EP - 51

JO - National Cancer Institute. Journal (Online)

JF - National Cancer Institute. Journal (Online)

IS - 1

ER -