Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis

B Bay; J Lyngsø; L Hohwü; U S Kesmodel

doi:10.1111/1471-0528.15456

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis

B Bay, J Lyngsø, L Hohwü, U S Kesmodel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

34 Citationer (Scopus)

10 Downloads (Pure)

Abstract

BACKGROUND: Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited.

OBJECTIVE: To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.

SEARCH STRATEGY: A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.

SELECTION CRITERIA: Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.

DATA COLLECTION AND ANALYSIS: Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale.

MAIN RESULTS: Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height.

CONCLUSIONS: In vitro fertilisation/ICSI was not associated with long-term weight and height.

TWEETABLE ABSTRACT: Children born following IVF/ICSI do not have impaired long-term weight or height compared with spontaneously conceived children.

Originalsprog	Engelsk
Tidsskrift	B J O G
Vol/bind	126
Udgave nummer	2
Sider (fra-til)	158-166
Antal sider	9
ISSN	1470-0328
DOI	https://doi.org/10.1111/1471-0528.15456
Status	Udgivet - jan. 2019

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Adgang til dokumentet

10.1111/1471-0528.15456

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection (Accepted Manuscript)Accepteret manuskript, 1,17 MB

Citationsformater

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title = "Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis",

abstract = "BACKGROUND: Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited.OBJECTIVE: To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.SEARCH STRATEGY: A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.SELECTION CRITERIA: Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.DATA COLLECTION AND ANALYSIS: Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale.MAIN RESULTS: Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height.CONCLUSIONS: In vitro fertilisation/ICSI was not associated with long-term weight and height.TWEETABLE ABSTRACT: Children born following IVF/ICSI do not have impaired long-term weight or height compared with spontaneously conceived children.",

keywords = "Body Height, Body Weight, Case-Control Studies, Child, Child Development, Child, Preschool, Cohort Studies, Female, Fertilization in Vitro/adverse effects, Humans, Infant, Infant, Newborn, Pregnancy, Pregnancy Outcome, Risk Factors, Sperm Injections, Intracytoplasmic/adverse effects",

author = "B Bay and J Lyngs{\o} and L Hohw{\"u} and Kesmodel, {U S}",

note = "{\textcopyright} 2018 Royal College of Obstetricians and Gynaecologists.",

year = "2019",

month = jan,

doi = "10.1111/1471-0528.15456",

language = "English",

volume = "126",

pages = "158--166",

journal = "B J O G",

issn = "1470-0328",

publisher = "Wiley-Blackwell",

number = "2",

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TY - JOUR

T1 - Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection

T2 - a systematic review and meta-analysis

AU - Bay, B

AU - Lyngsø, J

AU - Hohwü, L

AU - Kesmodel, U S

PY - 2019/1

Y1 - 2019/1

N2 - BACKGROUND: Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited.OBJECTIVE: To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.SEARCH STRATEGY: A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.SELECTION CRITERIA: Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.DATA COLLECTION AND ANALYSIS: Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale.MAIN RESULTS: Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height.CONCLUSIONS: In vitro fertilisation/ICSI was not associated with long-term weight and height.TWEETABLE ABSTRACT: Children born following IVF/ICSI do not have impaired long-term weight or height compared with spontaneously conceived children.

AB - BACKGROUND: Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited.OBJECTIVE: To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.SEARCH STRATEGY: A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.SELECTION CRITERIA: Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.DATA COLLECTION AND ANALYSIS: Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale.MAIN RESULTS: Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height.CONCLUSIONS: In vitro fertilisation/ICSI was not associated with long-term weight and height.TWEETABLE ABSTRACT: Children born following IVF/ICSI do not have impaired long-term weight or height compared with spontaneously conceived children.

KW - Body Height

KW - Body Weight

KW - Case-Control Studies

KW - Child

KW - Child Development

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - Fertilization in Vitro/adverse effects

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Pregnancy

KW - Pregnancy Outcome

KW - Risk Factors

KW - Sperm Injections, Intracytoplasmic/adverse effects

U2 - 10.1111/1471-0528.15456

DO - 10.1111/1471-0528.15456

M3 - Journal article

C2 - 30168249

SN - 1470-0328

VL - 126

SP - 158

EP - 166

JO - B J O G

JF - B J O G

IS - 2

ER -