TY - JOUR
T1 - Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation
AU - Schiffman, Jason
AU - Pestle, Sarah
AU - Mednick, Sara
AU - Ekstrom, Morten
AU - Sørensen, Holger Jelling
AU - Mednick, Sarnoff
N1 - Keywords: Adolescent; Adult; Child; Diagnostic and Statistical Manual of Mental Disorders; Dominance, Ocular; Female; Follow-Up Studies; Foot; Functional Laterality; Hand; Humans; Male; Prospective Studies; Questionnaires; Schizophrenia
PY - 2005
Y1 - 2005
N2 - Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indications of lateralization abnormalities may be evident prior to the onset of schizophrenia, suggesting that disruptions in lateralization are inherent to the developmental course of the disorder. We attempted to replicate and extend upon findings indicating differences in lateralization between children who later developed a schizophrenia spectrum disorder (n = 26) and those who did not develop a schizophrenia spectrum disorder (n = 216), among a high-risk and control, longitudinal sample. The rate of left or mixed-footedness, eye dominance, and any anomalous lateralization, but not handedness, discriminated between those who developed schizophrenia spectrum disorders and those who did not. Left or mixed-laterality appears to signal neurological disruption relevant to the development of schizophrenia spectrum disorders.
AB - Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indications of lateralization abnormalities may be evident prior to the onset of schizophrenia, suggesting that disruptions in lateralization are inherent to the developmental course of the disorder. We attempted to replicate and extend upon findings indicating differences in lateralization between children who later developed a schizophrenia spectrum disorder (n = 26) and those who did not develop a schizophrenia spectrum disorder (n = 216), among a high-risk and control, longitudinal sample. The rate of left or mixed-footedness, eye dominance, and any anomalous lateralization, but not handedness, discriminated between those who developed schizophrenia spectrum disorders and those who did not. Left or mixed-laterality appears to signal neurological disruption relevant to the development of schizophrenia spectrum disorders.
U2 - 10.1016/j.schres.2004.04.003
DO - 10.1016/j.schres.2004.04.003
M3 - Journal article
SN - 0920-9964
VL - 72
SP - 151
EP - 160
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -