@article{6cbaf4fbd4424878a82cda97e5300e59,
title = "Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians",
abstract = "S-Mephenytoin and chloroguanide (proguanil) oxidation was studied in 216 tanzanians. The mephenytoin S/R ratio in urine ranged from 0.9, were arbitrarily defined as poor metabolizers of mephenytoin. The chloroguanide/cycloguanil ratio ranged from 0.82 to 249. There was a significant correlation between the mephenytoin S/R ratio and the chloroguanide/cycloguanil ratios (rs = 0.73; p",
keywords = "Adult, Aged, Anticonvulsants, Antimalarials, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 Enzyme System, Female, Humans, Malaria, Male, Mephenytoin, Middle Aged, Mixed Function Oxygenases, Oxidation-Reduction, Proguanil, Tanzania",
author = "E Skjelbo and Mutabingwa, {T K} and Bygbjerg, {Ib Christian} and Nielsen, {K K} and Gram, {L F} and K Br{\o}osen",
year = "1996",
month = mar,
day = "1",
doi = "10.1016/S0009-9236(96)80008-7",
language = "English",
volume = "59",
pages = "304--11",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "3",
}