TY - JOUR
T1 - Choreography of recombination proteins during the DNA damage response
AU - Lisby, Michael
AU - Rothstein, Rodney
N1 - Keywords: Animals; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Humans; Nuclear Proteins; Recombination, Genetic; Signal Transduction
PY - 2009
Y1 - 2009
N2 - Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.
AB - Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.
U2 - 10.1016/j.dnarep.2009.04.007
DO - 10.1016/j.dnarep.2009.04.007
M3 - Journal article
C2 - 19473884
VL - 8
SP - 1068
EP - 1076
JO - DNA Repair
JF - DNA Repair
SN - 1568-7864
IS - 9
ER -