Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

Rong Jiang, Beverly H Brummett, Elizabeth R Hauser, Michael A Babyak, Ilene C Siegler, Abanish Singh, Arne Astrup, Oluf Pedersen, Torben Hansen, Claus Holst, Thorkild I A Sørensen, Redford B Williams

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

9 Citationer (Scopus)

Abstract

TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.
OriginalsprogEngelsk
TidsskriftBiological Psychology
Vol/bind93
Udgave nummer1
Sider (fra-til)184-189
Antal sider6
ISSN0301-0511
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 055

Citationsformater