TY - JOUR
T1 - Chronic lithium treatment with or without haloperidol fails to affect the morphology of the rat cerebellum
AU - Licht, R W
AU - Larsen, Jytte Overgaard
AU - Smith, D
AU - Braendgaard, H
N1 - Keywords: Animals; Antipsychotic Agents; Body Weight; Cell Count; Cell Size; Cerebellum; Female; Haloperidol; Lithium; Purkinje Cells; Rats; Rats, Wistar
PY - 2003
Y1 - 2003
N2 - We used unbiased stereological principles to determine whether long-term administration of lithium at human therapeutic levels, with or without haloperidol, affects the number or sizes of cerebellar Purkinje cells or the volume of histological layers in the rat cerebellum. Twenty-eight rats were randomly divided into three groups, receiving either no treatment, lithium, or lithium combined with haloperidol. The serum lithium levels ranged from 0.50 to 0.77 mmol/l. Haloperidol was given at a daily dose of 1 mg/kg. After 30 weeks of treatment, the animals were killed and the cerebelli were histologically prepared. No statistically significant differences were observed between the groups with respect to the cerebellar measures.
AB - We used unbiased stereological principles to determine whether long-term administration of lithium at human therapeutic levels, with or without haloperidol, affects the number or sizes of cerebellar Purkinje cells or the volume of histological layers in the rat cerebellum. Twenty-eight rats were randomly divided into three groups, receiving either no treatment, lithium, or lithium combined with haloperidol. The serum lithium levels ranged from 0.50 to 0.77 mmol/l. Haloperidol was given at a daily dose of 1 mg/kg. After 30 weeks of treatment, the animals were killed and the cerebelli were histologically prepared. No statistically significant differences were observed between the groups with respect to the cerebellar measures.
M3 - Journal article
C2 - 12729942
VL - 13
SP - 173
EP - 176
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 3
ER -