Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

Tina Ronn; Alexander Perfilyev; Josefine Jonsson; Karl-Fredrik Eriksson; Sine W. Jorgensen; Charlotte Brons; Linn Gillberg; Allan Vaag; Elisabet Stener-Victorin; Charlotte Ling

doi:10.1093/hmg/ddad024

Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

Tina Ronn, Alexander Perfilyev, Josefine Jonsson, Karl-Fredrik Eriksson, Sine W. Jorgensen, Charlotte Brons, Linn Gillberg, Allan Vaag, Elisabet Stener-Victorin, Charlotte Ling^*

^*Corresponding author af dette arbejde

Exercise and Muscle

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

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Abstract

Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P

Originalsprog	Engelsk
Tidsskrift	Human Molecular Genetics
Vol/bind	32
Udgave nummer	11
Sider (fra-til)	1875–1887
ISSN	0964-6906
DOI	https://doi.org/10.1093/hmg/ddad024
Status	Udgivet - 2023

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10.1093/hmg/ddad024Licens: CC BY-NC

FulltextForlagets udgivne version, 1,49 MBLicens: CC BY-NC

Citationsformater

Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. / Ronn, Tina; Perfilyev, Alexander; Jonsson, Josefine; Eriksson, Karl-Fredrik; Jorgensen, Sine W.; Brons, Charlotte; Gillberg, Linn ; Vaag, Allan; Stener-Victorin, Elisabet; Ling, Charlotte.

I: Human Molecular Genetics, Bind 32, Nr. 11, 2023, s. 1875–1887.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ronn, Tina ; Perfilyev, Alexander ; Jonsson, Josefine ; Eriksson, Karl-Fredrik ; Jorgensen, Sine W. ; Brons, Charlotte ; Gillberg, Linn ; Vaag, Allan ; Stener-Victorin, Elisabet ; Ling, Charlotte. / Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. I: Human Molecular Genetics. 2023 ; Bind 32, Nr. 11. s. 1875–1887.

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abstract = "Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P",

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author = "Tina Ronn and Alexander Perfilyev and Josefine Jonsson and Karl-Fredrik Eriksson and Jorgensen, {Sine W.} and Charlotte Brons and Linn Gillberg and Allan Vaag and Elisabet Stener-Victorin and Charlotte Ling",

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T1 - Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

AU - Ronn, Tina

AU - Perfilyev, Alexander

AU - Jonsson, Josefine

AU - Eriksson, Karl-Fredrik

AU - Jorgensen, Sine W.

AU - Brons, Charlotte

AU - Gillberg, Linn

AU - Vaag, Allan

AU - Stener-Victorin, Elisabet

AU - Ling, Charlotte

PY - 2023

Y1 - 2023

N2 - Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P

AB - Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P

KW - EPIGENETIC CHANGES

KW - BIOMARKERS

KW - DISCOVERY

KW - PROTEIN

KW - ISLETS

KW - AGE

U2 - 10.1093/hmg/ddad024

DO - 10.1093/hmg/ddad024

M3 - Journal article

C2 - 36752523

VL - 32

SP - 1875

EP - 1887

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 11

ER -