TY - JOUR
T1 - Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study
AU - von Linstow, Marie-Louise
AU - Høgh, Mette
AU - Høgh, Birthe
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus that has been detected in respiratory samples from children with acute respiratory tract infection (ARTI) and in feces from children with gastroenteritis. However, its role as a causative agent of respiratory disease is not determined. METHODS: We investigated the presence of HBoV by real-time polymerase-chain reaction of nasal swab specimens obtained from 228 healthy children followed in the community from birth to 1 year of age for a 2-year period from 2004 to 2006. Nasal swabs and symptom diaries were collected at monthly home visits. RESULTS: HBoV was detected in 57 (8.2%) of 697 nasal swab specimens from children with ARTI, in 1 (2.3%) of 44 swabs from children with diarrhea, and in 13 (8.6%) of 152 swabs from asymptomatic children. HBoV was present mainly during the winter months. An additional respiratory virus was identified in 27 (47.4%) HBoV-positive samples. Thirty-four (68%) of 50 children with ARTI shed HBoV for less than 1 month, 13 (26%) for 2 months, 2 (4%) for 3 months, and 1 (2%) for 4 months. Seven asymptomatic children shed HBoV for less than 1 month, 2 children for 2 months, and 1 asymptomatic child had 5 HBoV-positive nasal swabs detected for 6 consecutive months. HBoV infection was associated with maternal smoking, being born in the winter, and predisposition to asthma. CONCLUSIONS: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness
Udgivelsesdato: 2008/10
AB - BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus that has been detected in respiratory samples from children with acute respiratory tract infection (ARTI) and in feces from children with gastroenteritis. However, its role as a causative agent of respiratory disease is not determined. METHODS: We investigated the presence of HBoV by real-time polymerase-chain reaction of nasal swab specimens obtained from 228 healthy children followed in the community from birth to 1 year of age for a 2-year period from 2004 to 2006. Nasal swabs and symptom diaries were collected at monthly home visits. RESULTS: HBoV was detected in 57 (8.2%) of 697 nasal swab specimens from children with ARTI, in 1 (2.3%) of 44 swabs from children with diarrhea, and in 13 (8.6%) of 152 swabs from asymptomatic children. HBoV was present mainly during the winter months. An additional respiratory virus was identified in 27 (47.4%) HBoV-positive samples. Thirty-four (68%) of 50 children with ARTI shed HBoV for less than 1 month, 13 (26%) for 2 months, 2 (4%) for 3 months, and 1 (2%) for 4 months. Seven asymptomatic children shed HBoV for less than 1 month, 2 children for 2 months, and 1 asymptomatic child had 5 HBoV-positive nasal swabs detected for 6 consecutive months. HBoV infection was associated with maternal smoking, being born in the winter, and predisposition to asthma. CONCLUSIONS: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness
Udgivelsesdato: 2008/10
U2 - 10.1097/INF.0b013e3181757b16
DO - 10.1097/INF.0b013e3181757b16
M3 - Journal article
C2 - 18756188
VL - 27
SP - 897
EP - 902
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 10
ER -