TY - JOUR
T1 - Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy
AU - Jensen, L H
AU - Altaf, R
AU - Harling, H
AU - Jensen, M
AU - Laurberg, S
AU - Muhic, A
AU - Vestermark, L
AU - Jakobsen, A
AU - Bülow, S
AU - Jess, Danish Colorectal Cancer Group, Per
N1 - Keywords: Adult; Aged; Aged, 80 and over; Colectomy; Denmark; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Preoperative Care; Prospective Studies; Rectal Neoplasms; Survival Rate; Time Factors; Treatment Outcome
PY - 2010
Y1 - 2010
N2 - AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.
AB - AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.
U2 - 10.1016/j.ejso.2009.10.008
DO - 10.1016/j.ejso.2009.10.008
M3 - Journal article
C2 - 19880268
SN - 0748-7983
VL - 36
SP - 237
EP - 243
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 3
ER -