Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy

Martin Busk; Steen D Kristensen; Klaus Rasmussen; Henning Kelbaek; Per Thayssen; Jan K Madsen; Ulrik Abildgaard; Lars R Krusell; Leif S Mortensen; Leif Thuesen; Henning R Andersen; Torsten T Nielsen; DANAMI-2 Investigators

doi:10.1159/000171069

Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy

Martin Busk, Steen D Kristensen, Klaus Rasmussen, Henning Kelbaek, Per Thayssen, Jan K Madsen, Ulrik Abildgaard, Lars R Krusell, Leif S Mortensen, Leif Thuesen, Henning R Andersen, Torsten T Nielsen, DANAMI-2 Investigators

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-null

Originalsprog	Engelsk
Tidsskrift	Cardiology
Vol/bind	113
Udgave nummer	1
Sider (fra-til)	72-80
Antal sider	8
ISSN	0008-6312
DOI	https://doi.org/10.1159/000171069
Status	Udgivet - 2008

Bibliografisk note

Adgang til dokumentet

10.1159/000171069

Citationsformater

Busk, M., Kristensen, S. D., Rasmussen, K., Kelbaek, H., Thayssen, P., Madsen, J. K., Abildgaard, U., Krusell, L. R., Mortensen, L. S., Thuesen, L., Andersen, H. R., Nielsen, T. T., & DANAMI-2 Investigators (2008). Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy. Cardiology, 113(1), 72-80. https://doi.org/10.1159/000171069

Busk, M, Kristensen, SD, Rasmussen, K, Kelbaek, H, Thayssen, P, Madsen, JK, Abildgaard, U, Krusell, LR, Mortensen, LS, Thuesen, L, Andersen, HR, Nielsen, TT & DANAMI-2 Investigators 2008, 'Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy', Cardiology, bind 113, nr. 1, s. 72-80. https://doi.org/10.1159/000171069

@article{95ab726064ba11df928f000ea68e967b,

title = "Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy",

abstract = "OBJECTIVES: To evaluate clinical reinfarction during a 3-year follow-up after randomization to primary angioplasty versus fibrinolysis in anterior and non-anterior ST elevation myocardial infarction (STEMI). METHODS: Clinical reinfarction was prospectively assessed by an endpoint committee blinded to the study treatment. RESULTS: At 30 days, primary angioplasty compared with fibrinolysis reduced the reinfarction rate both in anterior STEMI patients (n = 823; 2.5 vs. 5.6%, p = 0.02) and in non-anterior STEMI patients (n = 743; 0.8 vs. 7.4%, p < 0.001). After 3 years, the reduction in reinfarction rate was no longer present in anterior STEMI patients (11.2 vs. 11.2%, p = 0.86), but persisted in non-anterior STEMI patients (5.2 vs. 13.5%, p < 0.001). Reinfarction after anterior STEMI carried a higher mortality than reinfarction after non-anterior STEMI (37.6 vs. 15.3%, p = 0.01). Independent predictors of death were: age [hazard ratio (HR) per 1-year increase in age = 1.08 (1.07-1.09)], clinical reinfarction [HR = 5.15 (3.57-7.43)], anterior index STEMI [HR = 1.65 (1.24-2.19)], and Killip class > or =2 [HR = 1.42 (1.01-2.00)]. The additional late reinfarctions after angioplasty for anterior STEMI were located within the angioplasty-treated target segment. Anterior STEMI patients had smaller mean target vessel diameter, which was associated with reinfarction. CONCLUSIONS: Clinical reinfarction is an independent predictor of death. The early superiority of primary angioplasty over fibrinolysis on reinfarction rate after anterior STEMI diminished during long-term follow-up.",

author = "Martin Busk and Kristensen, {Steen D} and Klaus Rasmussen and Henning Kelbaek and Per Thayssen and Madsen, {Jan K} and Ulrik Abildgaard and Krusell, {Lars R} and Mortensen, {Leif S} and Leif Thuesen and Andersen, {Henning R} and Nielsen, {Torsten T} and {DANAMI-2 Investigators}",

note = "Keywords: Aged; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Randomized Controlled Trials as Topic; Recurrence",

year = "2008",

doi = "10.1159/000171069",

language = "English",

volume = "113",

pages = "72--80",

journal = "Cardiology",

issn = "0008-6312",

publisher = "S Karger AG",

number = "1",

}

TY - JOUR

T1 - Clinical reinfarction according to infarct location and reperfusion modality in patients with ST elevation myocardial infarction. A DANAMI-2 long-term follow-up substudy

AU - Busk, Martin

AU - Kristensen, Steen D

AU - Rasmussen, Klaus

AU - Kelbaek, Henning

AU - Thayssen, Per

AU - Madsen, Jan K

AU - Abildgaard, Ulrik

AU - Krusell, Lars R

AU - Mortensen, Leif S

AU - Thuesen, Leif

AU - Andersen, Henning R

AU - Nielsen, Torsten T

AU - DANAMI-2 Investigators

N1 - Keywords: Aged; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Randomized Controlled Trials as Topic; Recurrence

PY - 2008

Y1 - 2008

N2 - OBJECTIVES: To evaluate clinical reinfarction during a 3-year follow-up after randomization to primary angioplasty versus fibrinolysis in anterior and non-anterior ST elevation myocardial infarction (STEMI). METHODS: Clinical reinfarction was prospectively assessed by an endpoint committee blinded to the study treatment. RESULTS: At 30 days, primary angioplasty compared with fibrinolysis reduced the reinfarction rate both in anterior STEMI patients (n = 823; 2.5 vs. 5.6%, p = 0.02) and in non-anterior STEMI patients (n = 743; 0.8 vs. 7.4%, p < 0.001). After 3 years, the reduction in reinfarction rate was no longer present in anterior STEMI patients (11.2 vs. 11.2%, p = 0.86), but persisted in non-anterior STEMI patients (5.2 vs. 13.5%, p < 0.001). Reinfarction after anterior STEMI carried a higher mortality than reinfarction after non-anterior STEMI (37.6 vs. 15.3%, p = 0.01). Independent predictors of death were: age [hazard ratio (HR) per 1-year increase in age = 1.08 (1.07-1.09)], clinical reinfarction [HR = 5.15 (3.57-7.43)], anterior index STEMI [HR = 1.65 (1.24-2.19)], and Killip class > or =2 [HR = 1.42 (1.01-2.00)]. The additional late reinfarctions after angioplasty for anterior STEMI were located within the angioplasty-treated target segment. Anterior STEMI patients had smaller mean target vessel diameter, which was associated with reinfarction. CONCLUSIONS: Clinical reinfarction is an independent predictor of death. The early superiority of primary angioplasty over fibrinolysis on reinfarction rate after anterior STEMI diminished during long-term follow-up.

AB - OBJECTIVES: To evaluate clinical reinfarction during a 3-year follow-up after randomization to primary angioplasty versus fibrinolysis in anterior and non-anterior ST elevation myocardial infarction (STEMI). METHODS: Clinical reinfarction was prospectively assessed by an endpoint committee blinded to the study treatment. RESULTS: At 30 days, primary angioplasty compared with fibrinolysis reduced the reinfarction rate both in anterior STEMI patients (n = 823; 2.5 vs. 5.6%, p = 0.02) and in non-anterior STEMI patients (n = 743; 0.8 vs. 7.4%, p < 0.001). After 3 years, the reduction in reinfarction rate was no longer present in anterior STEMI patients (11.2 vs. 11.2%, p = 0.86), but persisted in non-anterior STEMI patients (5.2 vs. 13.5%, p < 0.001). Reinfarction after anterior STEMI carried a higher mortality than reinfarction after non-anterior STEMI (37.6 vs. 15.3%, p = 0.01). Independent predictors of death were: age [hazard ratio (HR) per 1-year increase in age = 1.08 (1.07-1.09)], clinical reinfarction [HR = 5.15 (3.57-7.43)], anterior index STEMI [HR = 1.65 (1.24-2.19)], and Killip class > or =2 [HR = 1.42 (1.01-2.00)]. The additional late reinfarctions after angioplasty for anterior STEMI were located within the angioplasty-treated target segment. Anterior STEMI patients had smaller mean target vessel diameter, which was associated with reinfarction. CONCLUSIONS: Clinical reinfarction is an independent predictor of death. The early superiority of primary angioplasty over fibrinolysis on reinfarction rate after anterior STEMI diminished during long-term follow-up.

U2 - 10.1159/000171069

DO - 10.1159/000171069

M3 - Journal article

C2 - 19005253

SN - 0008-6312

VL - 113

SP - 72

EP - 80

JO - Cardiology

JF - Cardiology

IS - 1

ER -