TY - JOUR
T1 - Clinical Significance, Species Distribution, and Temporal Trends of Nontuberculous Mycobacteria, Denmark, 1991–2022
AU - Dahl, Victor Naestholt
AU - Pedersen, Andreas Arnholdt
AU - Norman, Anders
AU - Rasmussen, E. Michael
AU - van Ingen, Jakko
AU - Andersen, Aase Bengaard
AU - Wejse, Christian Morberg
AU - Lillebaek, Troels
N1 - Funding Information:
This study, performed as part of a PhD project, has been funded by a 2024 grant from the European Society of Clinical Microbiology and Infectious Diseases (to V.N.D.). In addition, V.N.D. received funding from the Department of Public Health, Aarhus University, Fonden af 17-12-1981, Skibsreder Per Henriksen, R. og hustrus fond, Health Research Foundation of Central Denmark Region, Christian Larsen og dommer Ellen Larsens Legat, Helga og Peter Kornings Fond, Beckett Foundation, the A.P. Moller Foundation (Fonden for L\u00E6gevidenskabens Fremme) and Denmark\u2019s Ministry of Higher Education and Science (Elite Research Travel Grant, 2023). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
Publisher Copyright:
© 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2024
Y1 - 2024
N2 - Nontuberculous mycobacteria (NTM) are emerging as notable causative agents of opportunistic infections. To examine clinical significance, species distribution, and temporal trends of NTM in Denmark, we performed a nationwide register-based study of all unique persons with NTM isolated in the country during 1991–2022. We categorized patients as having definite disease, possible disease, or isolation by using a previously validated method. The incidence of pulmonary NTM increased throughout the study period, in contrast to earlier findings. Mycobacterium malmoense, M. kansasii, M. szulgai, and M. avium complex were the most clinically significant species based on microbiologic findings; M. avium dominated in incidence. This study shows the need for surveillance for an emerging infection that is not notifiable in most countries, provides evidence to support clinical decision-making, and highlights the importance of not considering NTM as a single entity.
AB - Nontuberculous mycobacteria (NTM) are emerging as notable causative agents of opportunistic infections. To examine clinical significance, species distribution, and temporal trends of NTM in Denmark, we performed a nationwide register-based study of all unique persons with NTM isolated in the country during 1991–2022. We categorized patients as having definite disease, possible disease, or isolation by using a previously validated method. The incidence of pulmonary NTM increased throughout the study period, in contrast to earlier findings. Mycobacterium malmoense, M. kansasii, M. szulgai, and M. avium complex were the most clinically significant species based on microbiologic findings; M. avium dominated in incidence. This study shows the need for surveillance for an emerging infection that is not notifiable in most countries, provides evidence to support clinical decision-making, and highlights the importance of not considering NTM as a single entity.
U2 - 10.3201/eid3009.240095
DO - 10.3201/eid3009.240095
M3 - Journal article
C2 - 39173666
AN - SCOPUS:85201999936
VL - 30
SP - 1755
EP - 1762
JO - Emerging Infectious Diseases (Online)
JF - Emerging Infectious Diseases (Online)
SN - 1080-6040
IS - 9
ER -