Clozapine-associated neutropenia following augmentation with sodium valproate

Michelle Iris Jakobsen*, H. Grønborg, H. V. Hansen, A. Fink-Jensen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

4 Citationer (Scopus)
13 Downloads (Pure)

Abstract

Clozapine is gold standard for the management of treatment-resistant schizophrenia. It can offer life-changing symptom reduction where other antipsychotics have failed, and for these patients, treatment with clozapine should be maintained, if in any possible way. However, treatment with clozapine comes with a risk of developing potentially fatal adverse reactions, for example, severe neutropenia or agranulocytosis, in which case, treatment must be discontinued. Here, we present a case of clozapine-related neutropenia that commenced after the addition of sodium valproate. A subsequent re-challenge to clozapine resulted in severe neutropenia and led to the permanent cessation of clozapine treatment. The patient had been tolerating clozapine for more than a year before the addition of sodium valproate. The awareness of an interaction between clozapine and sodium valproate could help reduce the risk of clozapine-induced neutropenia and subsequent clozapine discontinuation.

OriginalsprogEngelsk
TidsskriftSage Open Medical Case Reports
Vol/bind9
Antal sider3
ISSN2050-313X
DOI
StatusUdgivet - 2021

Bibliografisk note

Publisher Copyright:
© The Author(s) 2021.

Citationsformater