TY - JOUR
T1 - Co-ordinating innate and adaptive immunity to viral infection: mobility is the key
AU - Wern, Jeanette Erbo
AU - Thomsen, Allan Randrup
N1 - Keywords: Animals; Antibodies, Viral; Cell Communication; Chemotaxis, Leukocyte; Cytokines; Dendritic Cells; Host-Pathogen Interactions; Humans; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Leukocytes; Lymphocyte Subsets; Macrophages; Monocytes; Receptors, Cytokine; Receptors, Pattern Recognition; Virus Diseases
PY - 2009
Y1 - 2009
N2 - The host counters a viral infection through a complex response made up of components belonging to both the innate and the adaptive immune system. In this report, we review the mechanisms underlying this response, how it is induced and how it is co-ordinated. As cell-cell communication represents the very essence of immune system physiology, a key to a rapid, efficient and optimally regulated immune response is the ability of the involved cells to rapidly shift between a stationary and a mobile state, combined with stringent regulation of cell migration during the mobile state. Through the co-ordinated recruitment of different cell types intended to work in concert, cellular co-operation is optimized particularly under conditions that may involve rare cells. Consequently, a major focus is placed on presenting an overview of the co-operative events and the associated cell migration, which is essential in mounting an efficient host response and co-ordinating innate and adaptive immunity during a primary viral infection.
AB - The host counters a viral infection through a complex response made up of components belonging to both the innate and the adaptive immune system. In this report, we review the mechanisms underlying this response, how it is induced and how it is co-ordinated. As cell-cell communication represents the very essence of immune system physiology, a key to a rapid, efficient and optimally regulated immune response is the ability of the involved cells to rapidly shift between a stationary and a mobile state, combined with stringent regulation of cell migration during the mobile state. Through the co-ordinated recruitment of different cell types intended to work in concert, cellular co-operation is optimized particularly under conditions that may involve rare cells. Consequently, a major focus is placed on presenting an overview of the co-operative events and the associated cell migration, which is essential in mounting an efficient host response and co-ordinating innate and adaptive immunity during a primary viral infection.
U2 - 10.1111/j.1600-0463.2009.02451.x
DO - 10.1111/j.1600-0463.2009.02451.x
M3 - Journal article
C2 - 19400861
SN - 0903-4641
VL - 117
SP - 338
EP - 355
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica
IS - 5-6
ER -