Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso; Francesco Maria Calabrese; Achille Iolascon; Erling Mellerup

doi:10.1016/j.cancergen.2014.02.004

Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso, Francesco Maria Calabrese, Achille Iolascon, Erling Mellerup

Institut for Neurovidenskab

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

8 Citationer (Scopus)

Abstract

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).

Originalsprog	Engelsk
Tidsskrift	Cancer genetics and cytogenetics
Vol/bind	207
Udgave nummer	3
Sider (fra-til)	94-7
Antal sider	4
ISSN	0165-4608
DOI	https://doi.org/10.1016/j.cancergen.2014.02.004
Status	Udgivet - mar. 2014

Adgang til dokumentet

10.1016/j.cancergen.2014.02.004

Citationsformater

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title = "Combinations of genetic data in a study of neuroblastoma risk genotypes",

abstract = "Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).",

keywords = "Genotype, Humans, Neuroblastoma, Polymorphism, Single Nucleotide",

author = "Mario Capasso and Calabrese, {Francesco Maria} and Achille Iolascon and Erling Mellerup",

year = "2014",

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doi = "10.1016/j.cancergen.2014.02.004",

language = "English",

volume = "207",

pages = "94--7",

journal = "Cancer genetics and cytogenetics",

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TY - JOUR

T1 - Combinations of genetic data in a study of neuroblastoma risk genotypes

AU - Capasso, Mario

AU - Calabrese, Francesco Maria

AU - Iolascon, Achille

AU - Mellerup, Erling

PY - 2014/3

Y1 - 2014/3

N2 - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).

AB - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).

KW - Genotype

KW - Humans

KW - Neuroblastoma

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.cancergen.2014.02.004

DO - 10.1016/j.cancergen.2014.02.004

M3 - Journal article

C2 - 24726319

VL - 207

SP - 94

EP - 97

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

SN - 0165-4608

IS - 3

ER -