Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Lena Sønder Snogdal; Mette Wod; Niels Grarup; M Vestmar; Thomas Hempel Sparsø; T Jørgensen; Torsten Lauritzen; Henning Beck-Nielsen; J E Henriksen; Oluf Pedersen; Torben Hansen; K Højlund

doi:10.1007/s00125-011-2377-0

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Lena Sønder Snogdal, Mette Wod, Niels Grarup, M Vestmar, Thomas Hempel Sparsø, T Jørgensen, Torsten Lauritzen, Henning Beck-Nielsen, J E Henriksen, Oluf Pedersen, Torben Hansen, K Højlund

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Abstract

There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	2
Sider (fra-til)	340-8
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-011-2377-0
Status	Udgivet - 2012

Adgang til dokumentet

10.1007/s00125-011-2377-0

Citationsformater

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title = "Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes",

abstract = "There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.",

author = "Snogdal, {Lena S{\o}nder} and Mette Wod and Niels Grarup and M Vestmar and Spars{\o}, {Thomas Hempel} and T J{\o}rgensen and Torsten Lauritzen and Henning Beck-Nielsen and Henriksen, {J E} and Oluf Pedersen and Torben Hansen and K H{\o}jlund",

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doi = "10.1007/s00125-011-2377-0",

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journal = "Diabetologia",

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T1 - Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

AU - Snogdal, Lena Sønder

AU - Wod, Mette

AU - Grarup, Niels

AU - Vestmar, M

AU - Sparsø, Thomas Hempel

AU - Jørgensen, T

AU - Lauritzen, Torsten

AU - Beck-Nielsen, Henning

AU - Henriksen, J E

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Højlund, K

PY - 2012

Y1 - 2012

N2 - There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

AB - There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

U2 - 10.1007/s00125-011-2377-0

DO - 10.1007/s00125-011-2377-0

M3 - Journal article

C2 - 22095239

SN - 0012-186X

VL - 55

SP - 340

EP - 348

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -