Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study

Jens Jakob Thune; Lars Køber; Marc A Pfeffer; Hicham Skali; Nagesh S Anavekar; Mikhail Bourgoun; Jalal K Ghali; J Malcolm O Arnold; Eric J Velazquez; Scott D Solomon

doi:10.1016/j.echo.2006.05.028

Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study

Jens Jakob Thune, Lars Køber, Marc A Pfeffer, Hicham Skali, Nagesh S Anavekar, Mikhail Bourgoun, Jalal K Ghali, J Malcolm O Arnold, Eric J Velazquez, Scott D Solomon

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

43 Citationer (Scopus)

Abstract

Udgivelsesdato: 2006-Dec

Originalsprog	Engelsk
Tidsskrift	Journal of the American Society of Echocardiography
Vol/bind	19
Udgave nummer	12
Sider (fra-til)	1462-5
Antal sider	3
ISSN	0894-7317
DOI	https://doi.org/10.1016/j.echo.2006.05.028
Status	Udgivet - 2006

Bibliografisk note

Keywords: Aged; Antihypertensive Agents; Comorbidity; Echocardiography; Female; Heart Failure; Humans; Internationality; Male; Middle Aged; Myocardial Infarction; Prevalence; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Stroke Volume; Tetrazoles; Valine; Ventricular Dysfunction, Left

Adgang til dokumentet

10.1016/j.echo.2006.05.028

Citationsformater

Thune, J. J., Køber, L., Pfeffer, M. A., Skali, H., Anavekar, N. S., Bourgoun, M., Ghali, J. K., Arnold, J. M. O., Velazquez, E. J., & Solomon, S. D. (2006). Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study. Journal of the American Society of Echocardiography, 19(12), 1462-5. https://doi.org/10.1016/j.echo.2006.05.028

Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study. / Thune, Jens Jakob; Køber, Lars; Pfeffer, Marc A; Skali, Hicham; Anavekar, Nagesh S; Bourgoun, Mikhail; Ghali, Jalal K; Arnold, J Malcolm O; Velazquez, Eric J; Solomon, Scott D.

I: Journal of the American Society of Echocardiography, Bind 19, Nr. 12, 2006, s. 1462-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Thune, JJ, Køber, L, Pfeffer, MA, Skali, H, Anavekar, NS, Bourgoun, M, Ghali, JK, Arnold, JMO, Velazquez, EJ & Solomon, SD 2006, 'Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study', Journal of the American Society of Echocardiography, bind 19, nr. 12, s. 1462-5. https://doi.org/10.1016/j.echo.2006.05.028

Thune JJ, Køber L, Pfeffer MA, Skali H, Anavekar NS, Bourgoun M et al. Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study. Journal of the American Society of Echocardiography. 2006;19(12):1462-5. https://doi.org/10.1016/j.echo.2006.05.028

Thune, Jens Jakob ; Køber, Lars ; Pfeffer, Marc A ; Skali, Hicham ; Anavekar, Nagesh S ; Bourgoun, Mikhail ; Ghali, Jalal K ; Arnold, J Malcolm O ; Velazquez, Eric J ; Solomon, Scott D. / Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study. I: Journal of the American Society of Echocardiography. 2006 ; Bind 19, Nr. 12. s. 1462-5.

@article{efb83c10118711df803f000ea68e967b,

title = "Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study",

abstract = "BACKGROUND: Left ventricular (LV) ejection fraction (EF) and wall-motion index (WMI) have both been shown to be independent predictors of outcome after myocardial infarction (MI). OBJECTIVES: We sought to determine whether these two measurements of LV systolic function provide similar or complementary information about prognosis after MI. METHODS: Echocardiography was performed in 610 patients with LV dysfunction, heart failure, or both after MI enrolled in the Valsartan in Acute MI trial. LVEF was estimated by biplane Simpson's rule, and WMI was assessed using a 16-segment model in 502 patients with echocardiograms of sufficient quality for wall-motion assessment. RESULTS: Both LVEF and WMI were independent predictors of adverse outcome after MI. LVEF conferred no additional prognostic information in multivariable analysis including WMI (P = .39) or number of affected segments (P = .53), whereas WMI (P = .02) and total number of affected segments (P = .006) remained significant even when adjusting for LVEF. CONCLUSIONS: Assessment of regional dysfunction by WMI or the number of affected segments has slightly more prognostic value than LVEF in patients with LV dysfunction, heart failure, or both after MI. Regional assessment might be a more sensitive predictor of outcome than global assessment in patients with acute MI.",

author = "Thune, {Jens Jakob} and Lars K{\o}ber and Pfeffer, {Marc A} and Hicham Skali and Anavekar, {Nagesh S} and Mikhail Bourgoun and Ghali, {Jalal K} and Arnold, {J Malcolm O} and Velazquez, {Eric J} and Solomon, {Scott D}",

note = "Keywords: Aged; Antihypertensive Agents; Comorbidity; Echocardiography; Female; Heart Failure; Humans; Internationality; Male; Middle Aged; Myocardial Infarction; Prevalence; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Stroke Volume; Tetrazoles; Valine; Ventricular Dysfunction, Left",

year = "2006",

doi = "10.1016/j.echo.2006.05.028",

language = "English",

volume = "19",

pages = "1462--5",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study

AU - Thune, Jens Jakob

AU - Køber, Lars

AU - Pfeffer, Marc A

AU - Skali, Hicham

AU - Anavekar, Nagesh S

AU - Bourgoun, Mikhail

AU - Ghali, Jalal K

AU - Arnold, J Malcolm O

AU - Velazquez, Eric J

AU - Solomon, Scott D

N1 - Keywords: Aged; Antihypertensive Agents; Comorbidity; Echocardiography; Female; Heart Failure; Humans; Internationality; Male; Middle Aged; Myocardial Infarction; Prevalence; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Stroke Volume; Tetrazoles; Valine; Ventricular Dysfunction, Left

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Left ventricular (LV) ejection fraction (EF) and wall-motion index (WMI) have both been shown to be independent predictors of outcome after myocardial infarction (MI). OBJECTIVES: We sought to determine whether these two measurements of LV systolic function provide similar or complementary information about prognosis after MI. METHODS: Echocardiography was performed in 610 patients with LV dysfunction, heart failure, or both after MI enrolled in the Valsartan in Acute MI trial. LVEF was estimated by biplane Simpson's rule, and WMI was assessed using a 16-segment model in 502 patients with echocardiograms of sufficient quality for wall-motion assessment. RESULTS: Both LVEF and WMI were independent predictors of adverse outcome after MI. LVEF conferred no additional prognostic information in multivariable analysis including WMI (P = .39) or number of affected segments (P = .53), whereas WMI (P = .02) and total number of affected segments (P = .006) remained significant even when adjusting for LVEF. CONCLUSIONS: Assessment of regional dysfunction by WMI or the number of affected segments has slightly more prognostic value than LVEF in patients with LV dysfunction, heart failure, or both after MI. Regional assessment might be a more sensitive predictor of outcome than global assessment in patients with acute MI.

AB - BACKGROUND: Left ventricular (LV) ejection fraction (EF) and wall-motion index (WMI) have both been shown to be independent predictors of outcome after myocardial infarction (MI). OBJECTIVES: We sought to determine whether these two measurements of LV systolic function provide similar or complementary information about prognosis after MI. METHODS: Echocardiography was performed in 610 patients with LV dysfunction, heart failure, or both after MI enrolled in the Valsartan in Acute MI trial. LVEF was estimated by biplane Simpson's rule, and WMI was assessed using a 16-segment model in 502 patients with echocardiograms of sufficient quality for wall-motion assessment. RESULTS: Both LVEF and WMI were independent predictors of adverse outcome after MI. LVEF conferred no additional prognostic information in multivariable analysis including WMI (P = .39) or number of affected segments (P = .53), whereas WMI (P = .02) and total number of affected segments (P = .006) remained significant even when adjusting for LVEF. CONCLUSIONS: Assessment of regional dysfunction by WMI or the number of affected segments has slightly more prognostic value than LVEF in patients with LV dysfunction, heart failure, or both after MI. Regional assessment might be a more sensitive predictor of outcome than global assessment in patients with acute MI.

U2 - 10.1016/j.echo.2006.05.028

DO - 10.1016/j.echo.2006.05.028

M3 - Journal article

C2 - 17138030

VL - 19

SP - 1462

EP - 1465

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 12

ER -