Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting

Jens Drachmann Bukh; Martin Balslev Jørgensen; Henrik Dam; Per Plenge; Jens Drachmann Bukh; Martin Balslev Jørgensen; Henrik Dam; Per Plenge

doi:10.1080/08039480902799099

Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting

Jens Drachmann Bukh, Martin Balslev Jørgensen, Henrik Dam, Per Plenge, Jens Drachmann Bukh, Martin Balslev Jørgensen, Henrik Dam, Per Plenge

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009

Originalsprog	Engelsk
Tidsskrift	Nordic Journal of Psychiatry
Vol/bind	63
Udgave nummer	4
Sider (fra-til)	347-51
Antal sider	4
ISSN	0803-9488
DOI	https://doi.org/10.1080/08039480902799099 https://doi.org/10.1080/08039480902799099
Status	Udgivet - 2009

Bibliografisk note

Keywords: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Denmark; Depressive Disorder, Major; Dothiepin; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Treatment Outcome

Adgang til dokumentet

Citationsformater

@article{7c88c100a92711df928f000ea68e967b,

title = "Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting",

abstract = "The relative efficacy of the various classes of antidepressants has not been established. Observational studies in naturalistic settings are important in evaluating treatment outcomes with antidepressants, since controlled clinical trials include only a minority of patients present in clinical practice. This study sought to evaluate in a naturalistic setting the treatment outcomes of dosulepin and venlafaxine for patients with depressive episodes. At the university hospital in Copenhagen, Denmark, between 1998 and early 2001, the first-line treatment for psychiatric inpatients with depression was dosulepin; after that time, venlafaxine was the first-line medication. We compared the treatment outcomes among inpatients during the respective periods. There was no significant difference in the primary outcome parameters between the two groups. A tendency in favour of dosulepin confirmed by a post-hoc analysis suggested that the failure to achieve significant difference was related to a type 2 error. However, missing data and possible confounders related to the different treatment periods weaken the results. This naturalistic study showed a non-significant trend for poorer treatment outcomes (probably because of an underpowered design) after replacing dosulepin with venlafaxine as first-line drug for depression in a naturalistic inpatient setting.",

author = "Bukh, {Jens Drachmann} and J{\o}rgensen, {Martin Balslev} and Henrik Dam and Per Plenge and Bukh, {Jens Drachmann} and J{\o}rgensen, {Martin Balslev} and Henrik Dam and Per Plenge",

note = "Keywords: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Denmark; Depressive Disorder, Major; Dothiepin; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Treatment Outcome",

year = "2009",

doi = "10.1080/08039480902799099",

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TY - JOUR

T1 - Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting

AU - Bukh, Jens Drachmann

AU - Jørgensen, Martin Balslev

AU - Dam, Henrik

AU - Plenge, Per

AU - Bukh, Jens Drachmann

AU - Jørgensen, Martin Balslev

AU - Dam, Henrik

AU - Plenge, Per

N1 - Keywords: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Denmark; Depressive Disorder, Major; Dothiepin; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Treatment Outcome

PY - 2009

Y1 - 2009

N2 - The relative efficacy of the various classes of antidepressants has not been established. Observational studies in naturalistic settings are important in evaluating treatment outcomes with antidepressants, since controlled clinical trials include only a minority of patients present in clinical practice. This study sought to evaluate in a naturalistic setting the treatment outcomes of dosulepin and venlafaxine for patients with depressive episodes. At the university hospital in Copenhagen, Denmark, between 1998 and early 2001, the first-line treatment for psychiatric inpatients with depression was dosulepin; after that time, venlafaxine was the first-line medication. We compared the treatment outcomes among inpatients during the respective periods. There was no significant difference in the primary outcome parameters between the two groups. A tendency in favour of dosulepin confirmed by a post-hoc analysis suggested that the failure to achieve significant difference was related to a type 2 error. However, missing data and possible confounders related to the different treatment periods weaken the results. This naturalistic study showed a non-significant trend for poorer treatment outcomes (probably because of an underpowered design) after replacing dosulepin with venlafaxine as first-line drug for depression in a naturalistic inpatient setting.

AB - The relative efficacy of the various classes of antidepressants has not been established. Observational studies in naturalistic settings are important in evaluating treatment outcomes with antidepressants, since controlled clinical trials include only a minority of patients present in clinical practice. This study sought to evaluate in a naturalistic setting the treatment outcomes of dosulepin and venlafaxine for patients with depressive episodes. At the university hospital in Copenhagen, Denmark, between 1998 and early 2001, the first-line treatment for psychiatric inpatients with depression was dosulepin; after that time, venlafaxine was the first-line medication. We compared the treatment outcomes among inpatients during the respective periods. There was no significant difference in the primary outcome parameters between the two groups. A tendency in favour of dosulepin confirmed by a post-hoc analysis suggested that the failure to achieve significant difference was related to a type 2 error. However, missing data and possible confounders related to the different treatment periods weaken the results. This naturalistic study showed a non-significant trend for poorer treatment outcomes (probably because of an underpowered design) after replacing dosulepin with venlafaxine as first-line drug for depression in a naturalistic inpatient setting.

U2 - 10.1080/08039480902799099

DO - 10.1080/08039480902799099

M3 - Journal article

C2 - 19347769

SN - 0803-9488

VL - 63

SP - 347

EP - 351

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

IS - 4

ER -