Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Experimental Medicine |
| Vol/bind | 198 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1495-506 |
| Antal sider | 11 |
| ISSN | 0022-1007 |
| DOI | |
| Status | Udgivet - 2003 |
Bibliografisk note
Keywords: Animals; B-Lymphocytes; Cell Differentiation; Membrane Proteins; Mice; Mice, Knockout; Peyer's Patches; Receptors, Interleukin-7; Signal TransductionAdgang til dokumentet
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Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. / Sitnicka, Ewa; Brakebusch, Cord; Martensson, Inga-Lill; Svensson, Marcus; Agace, William W; Sigvardsson, Mikael; Buza-Vidas, Natalija; Bryder, David; Cilio, Corrado M; Ahlenius, Henrik; Maraskovsky, Eugene; Peschon, Jacques J; Jacobsen, Sten Eirik W.
I: Journal of Experimental Medicine, Bind 198, Nr. 10, 2003, s. 1495-506.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review
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TY - JOUR
T1 - Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.
AU - Sitnicka, Ewa
AU - Brakebusch, Cord
AU - Martensson, Inga-Lill
AU - Svensson, Marcus
AU - Agace, William W
AU - Sigvardsson, Mikael
AU - Buza-Vidas, Natalija
AU - Bryder, David
AU - Cilio, Corrado M
AU - Ahlenius, Henrik
AU - Maraskovsky, Eugene
AU - Peschon, Jacques J
AU - Jacobsen, Sten Eirik W
N1 - Keywords: Animals; B-Lymphocytes; Cell Differentiation; Membrane Proteins; Mice; Mice, Knockout; Peyer's Patches; Receptors, Interleukin-7; Signal Transduction
PY - 2003
Y1 - 2003
N2 - Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7Ralpha-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha-/- mice, FL-/- x IL-7Ralpha-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.
AB - Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7Ralpha-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha-/- mice, FL-/- x IL-7Ralpha-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.
U2 - 10.1084/jem.20031152
DO - 10.1084/jem.20031152
M3 - Journal article
C2 - 14610045
VL - 198
SP - 1495
EP - 1506
JO - The Journal of Experimental Medicine
JF - The Journal of Experimental Medicine
SN - 0022-1007
IS - 10
ER -