Composite likelihood method for inferring local pedigrees

Amy Ko*, Rasmus Nielsen

*Corresponding author af dette arbejde

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    13 Citationer (Scopus)
    303 Downloads (Pure)

    Abstract

    Pedigrees contain information about the genealogical relationships among individuals and are of fundamental importance in many areas of genetic studies. However, pedigrees are often unknown and must be inferred from genetic data. Despite the importance of pedigree inference, existing methods are limited to inferring only close relationships or analyzing a small number of individuals or loci. We present a simulated annealing method for estimating pedigrees in large samples of otherwise seemingly unrelated individuals using genome-wide SNP data. The method supports complex pedigree structures such as polygamous families, multi-generational families, and pedigrees in which many of the member individuals are missing. Computational speed is greatly enhanced by the use of a composite likelihood function which approximates the full likelihood. We validate our method on simulated data and show that it can infer distant relatives more accurately than existing methods. Furthermore, we illustrate the utility of the method on a sample of Greenlandic Inuit.

    OriginalsprogEngelsk
    Artikelnummere1006963
    TidsskriftPLoS Genetics
    Vol/bind13
    Udgave nummer8
    Antal sider21
    ISSN1553-7390
    DOI
    StatusUdgivet - 21 aug. 2017

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