TY - JOUR
T1 - COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia
AU - Haraldsson, H Magnus
AU - Ettinger, Ulrich
AU - Magnusdottir, Brynja B
AU - Sigmundsson, Thordur
AU - Sigurdsson, Engilbert
AU - Ingason, Andres
AU - Petursson, Hannes
N1 - Keywords: Adult; Analysis of Variance; Catechol O-Methyltransferase; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Middle Aged; Neuropsychological Tests; Ocular Motility Disorders; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Pursuit, Smooth; Reaction Time; Schizophrenia; Valine
PY - 2009
Y1 - 2009
N2 - The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.
AB - The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.
U2 - 10.1016/j.psychres.2008.10.003
DO - 10.1016/j.psychres.2008.10.003
M3 - Journal article
SN - 0165-1781
VL - 169
SP - 173
EP - 175
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2
ER -