Concise synthesis of new bridged-nicotine analogues

François Crestey, Geert Hooyberghs, Jesper Langgaard Kristensen

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    7 Citationer (Scopus)

    Abstract

    This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
    OriginalsprogEngelsk
    TidsskriftTetrahedron
    Vol/bind68
    Udgave nummer5
    Sider (fra-til)1417-1421
    ISSN0040-4020
    DOI
    StatusUdgivet - 4 feb. 2012

    Bibliografisk note

    Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination

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