Abstract
This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Tetrahedron |
Vol/bind | 68 |
Udgave nummer | 5 |
Sider (fra-til) | 1417-1421 |
ISSN | 0040-4020 |
DOI | |
Status | Udgivet - 4 feb. 2012 |
Bibliografisk note
Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive aminationEmneord
- Det tidligere Farmaceutiske Fakultet