Concise synthesis of new bridged-nicotine analogues

François Crestey; Geert  Hooyberghs; Jesper Langgaard Kristensen

doi:10.1016/j.tet.2011.12.029

Concise synthesis of new bridged-nicotine analogues

François Crestey, Geert Hooyberghs, Jesper Langgaard Kristensen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Abstract

This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

Originalsprog	Engelsk
Tidsskrift	Tetrahedron
Vol/bind	68
Udgave nummer	5
Sider (fra-til)	1417-1421
ISSN	0040-4020
DOI	https://doi.org/10.1016/j.tet.2011.12.029
Status	Udgivet - 4 feb. 2012

Bibliografisk note

Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1016/j.tet.2011.12.029

Citationsformater

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AU - Crestey, François

AU - Hooyberghs, Geert

AU - Kristensen, Jesper Langgaard

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PY - 2012/2/4

Y1 - 2012/2/4

N2 - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

AB - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.tet.2011.12.029

DO - 10.1016/j.tet.2011.12.029

M3 - Journal article

VL - 68

SP - 1417

EP - 1421

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 5

ER -