TY - JOUR
T1 - Constrained vertebrate evolution by pleiotropic genes
AU - Hu, Haiyang
AU - Uesaka, Masahiro
AU - Guo, Song
AU - Shimai, Kotaro
AU - Lu, Tsai-Ming
AU - Li, Fang
AU - Fujimoto, Satoko
AU - Ishikawa, Masato
AU - Liu, Shiping
AU - Sasagawa, Yohei
AU - Zhang, Guojie
AU - Kuratani, Shigeru
AU - Yu, Jr-Kai
AU - Kusakabe, Takehiro G.
AU - Khaitovich, Philipp
AU - Irie, Naoki
PY - 2017/11
Y1 - 2017/11
N2 - Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or 'bodyplan') remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic transcriptomes collected from eight chordates, we suggest that the phylotype hypothesis would be better applied to vertebrates than chordates. Furthermore, we found that vertebrates' conserved mid-embryonic developmental programmes are intensively recruited to other developmental processes, and the degree of the recruitment positively correlates with their evolutionary conservation and essentiality for normal development. Thus, we propose that the intensively recruited genetic system during vertebrates' organogenesis period imposed constraints on its diversification through pleiotropic constraints, which ultimately led to the common anatomical pattern observed in vertebrates.
AB - Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or 'bodyplan') remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic transcriptomes collected from eight chordates, we suggest that the phylotype hypothesis would be better applied to vertebrates than chordates. Furthermore, we found that vertebrates' conserved mid-embryonic developmental programmes are intensively recruited to other developmental processes, and the degree of the recruitment positively correlates with their evolutionary conservation and essentiality for normal development. Thus, we propose that the intensively recruited genetic system during vertebrates' organogenesis period imposed constraints on its diversification through pleiotropic constraints, which ultimately led to the common anatomical pattern observed in vertebrates.
UR - http://www.scopus.com/inward/record.url?scp=85031767166&partnerID=8YFLogxK
U2 - 10.1038/s41559-017-0318-0
DO - 10.1038/s41559-017-0318-0
M3 - Journal article
C2 - 28963548
AN - SCOPUS:85031767166
VL - 1
SP - 1722
EP - 1730
JO - Nature Ecology & Evolution
JF - Nature Ecology & Evolution
SN - 2397-334X
IS - 11
ER -