Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P Petersen; Anders Foller Larsen; Andreas Ritzén; Trond Ulven

doi:10.1021/jo400390t

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P Petersen, Anders Foller Larsen, Andreas Ritzén, Trond Ulven

LUKKET: Medicinal Chemistry Research

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

43 Citationer (Scopus)

Abstract

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

Originalsprog	Engelsk
Tidsskrift	Journal of Organic Chemistry
Vol/bind	78
Udgave nummer	8
Sider (fra-til)	4190-4195
Antal sider	6
ISSN	0022-3263
DOI	https://doi.org/10.1021/jo400390t
Status	Udgivet - 2013

Adgang til dokumentet

10.1021/jo400390t

Citationsformater

@article{ac01670bdb564a17af5627a92a754909,

title = "Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF",

abstract = "A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.",

author = "Petersen, {Trine P} and Larsen, {Anders Foller} and Andreas Ritz{\'e}n and Trond Ulven",

year = "2013",

doi = "10.1021/jo400390t",

language = "English",

volume = "78",

pages = "4190--4195",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

AU - Petersen, Trine P

AU - Larsen, Anders Foller

AU - Ritzén, Andreas

AU - Ulven, Trond

PY - 2013

Y1 - 2013

N2 - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

AB - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

U2 - 10.1021/jo400390t

DO - 10.1021/jo400390t

M3 - Journal article

SN - 0022-3263

VL - 78

SP - 4190

EP - 4195

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 8

ER -