Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies

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    58 Citationer (Scopus)

    Abstract

    Within-person variability in measured values of multiple risk factors can bias their associations with disease. The multivariate regression calibration (RC) approach can correct for such measurement error and has been applied to studies in which true values or independent repeat measurements of the risk factors are observed on a subsample. We extend the multivariate RC techniques to a meta-analysis framework where multiple studies provide independent repeat measurements and information on disease outcome. We consider the cases where some or all studies have repeat measurements, and compare study-specific, averaged and empirical Bayes estimates of RC parameters. Additionally, we allow for binary covariates (e.g. smoking status) and for uncertainty and time trends in the measurement error corrections. Our methods are illustrated using a subset of individual participant data from prospective long-term studies in the Fibrinogen Studies Collaboration to assess the relationship between usual levels of plasma fibrinogen and the risk of coronary heart disease, allowing for measurement error in plasma fibrinogen and several confounders
    Udgivelsesdato: 2009/3/30
    OriginalsprogEngelsk
    TidsskriftStatistics in Medicine
    Vol/bind28
    Udgave nummer7
    Sider (fra-til)1067-1092
    Antal sider25
    ISSN0277-6715
    StatusUdgivet - 2009

    Bibliografisk note

    The Fibrinogen Studies Collaboration.The Copenhagen City Heart Study

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