Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens

Susan Mayo; Felix Royo; Jann Hau

doi:10.1111/j.1600-0463.2005.apm_07.x

Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens

Susan Mayo^*, Felix Royo, Jann Hau

^*Corresponding author af dette arbejde

Afdeling for Eksperimentel Medicin, Forskning og Undervisning

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.

Originalsprog	Engelsk
Tidsskrift	APMIS
Vol/bind	113
Udgave nummer	4
Sider (fra-til)	284-287
Antal sider	4
ISSN	0903-4641
DOI	https://doi.org/10.1111/j.1600-0463.2005.apm_07.x
Status	Udgivet - apr. 2005

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title = "Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens",

abstract = "The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.",

keywords = "Adjuvant, Chicken, Cholera toxin B",

author = "Susan Mayo and Felix Royo and Jann Hau",

year = "2005",

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journal = "APMIS",

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T1 - Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens

AU - Mayo, Susan

AU - Royo, Felix

AU - Hau, Jann

PY - 2005/4

Y1 - 2005/4

N2 - The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.

AB - The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.

KW - Adjuvant

KW - Chicken

KW - Cholera toxin B

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U2 - 10.1111/j.1600-0463.2005.apm_07.x

DO - 10.1111/j.1600-0463.2005.apm_07.x

M3 - Journal article

C2 - 15865610

AN - SCOPUS:18744405366

SN - 0903-4641

VL - 113

SP - 284

EP - 287

JO - APMIS

JF - APMIS

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