Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Helena Bergsten; Martin Bruun Madsen; Francois Bergey; Ole Hyldegaard; Steinar Skrede; Per Arnell; Oddvar Oppegaard; Andreas Itzek; Anders Perner; Mattias Svensson; Anna Norrby-Teglund; INFECT Study Group

doi:10.1093/cid/ciaa022

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Helena Bergsten, Martin Bruun Madsen, Francois Bergey, Ole Hyldegaard, Steinar Skrede, Per Arnell, Oddvar Oppegaard, Andreas Itzek, Anders Perner, Mattias Svensson, Anna Norrby-Teglund, INFECT Study Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

22 Citationer (Scopus)

28 Downloads (Pure)

Abstract

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.

Originalsprog	Engelsk
Tidsskrift	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Vol/bind	71
Udgave nummer	7
Sider (fra-til)	1772-1775
Antal sider	4
ISSN	1058-4838
DOI	https://doi.org/10.1093/cid/ciaa022
Status	Udgivet - 2020

Adgang til dokumentet

10.1093/cid/ciaa022Licens: CC BY-NC-ND

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue InfectionsForlagets udgivne version, 523 KBLicens: CC BY-NC-ND

Citationsformater

Bergsten, H., Madsen, M. B., Bergey, F., Hyldegaard, O., Skrede, S., Arnell, P., Oppegaard, O., Itzek, A., Perner, A., Svensson, M., Norrby-Teglund, A., & INFECT Study Group (2020). Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(7), 1772-1775. https://doi.org/10.1093/cid/ciaa022

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections. / Bergsten, Helena; Madsen, Martin Bruun; Bergey, Francois et al.
I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Bind 71, Nr. 7, 2020, s. 1772-1775.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bergsten, H, Madsen, MB, Bergey, F, Hyldegaard, O, Skrede, S, Arnell, P, Oppegaard, O, Itzek, A, Perner, A, Svensson, M, Norrby-Teglund, A & INFECT Study Group 2020, 'Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, bind 71, nr. 7, s. 1772-1775. https://doi.org/10.1093/cid/ciaa022

Bergsten H, Madsen MB, Bergey F, Hyldegaard O, Skrede S, Arnell P et al. Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020;71(7):1772-1775. doi: 10.1093/cid/ciaa022

Bergsten, Helena ; Madsen, Martin Bruun ; Bergey, Francois et al. / Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections. I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 ; Bind 71, Nr. 7. s. 1772-1775.

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abstract = "Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.",

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author = "Helena Bergsten and Madsen, {Martin Bruun} and Francois Bergey and Ole Hyldegaard and Steinar Skrede and Per Arnell and Oddvar Oppegaard and Andreas Itzek and Anders Perner and Mattias Svensson and Anna Norrby-Teglund and {INFECT Study Group}",

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AU - Bergsten, Helena

AU - Madsen, Martin Bruun

AU - Bergey, Francois

AU - Hyldegaard, Ole

AU - Skrede, Steinar

AU - Arnell, Per

AU - Oppegaard, Oddvar

AU - Itzek, Andreas

AU - Perner, Anders

AU - Svensson, Mattias

AU - Norrby-Teglund, Anna

AU - INFECT Study Group

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AB - Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.

KW - Streptococcus pyogenes

KW - intravenous immunoglobulin G

KW - necrotizing fasciitis

KW - necrotizing soft tissue infections

KW - superantigens

U2 - 10.1093/cid/ciaa022

DO - 10.1093/cid/ciaa022

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JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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