Correlation between liver morphology and portal pressure in alcoholic liver disease

K Krogsgaard; C Gluud; Jens Henrik Sahl Henriksen; P Christoffersen

Correlation between liver morphology and portal pressure in alcoholic liver disease

K Krogsgaard, C Gluud, Jens Henrik Sahl Henriksen, P Christoffersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

57 Citationer (Scopus)

Abstract

Udgivelsesdato: null-null

Originalsprog	Engelsk
Tidsskrift	Hepatology
Vol/bind	4
Udgave nummer	4
Sider (fra-til)	699-703
Antal sider	4
ISSN	0270-9139
Status	Udgivet - 1984

Bibliografisk note

Keywords: Adult; Aged; Fatty Liver, Alcoholic; Female; Hepatic Veins; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Middle Aged; Necrosis; Venous Pressure

Citationsformater

@article{aa97b340462f11df928f000ea68e967b,

title = "Correlation between liver morphology and portal pressure in alcoholic liver disease",

abstract = "In 14 alcoholic patients, the degree of hepatic architectural destruction was graded (preserved architecture; nodules alternating with preserved architecture; totally destroyed architecture) and related to portal pressure. A positive correlation was found between the degree of architectural destruction and both wedged hepatic vein pressure (r = 0.72, p less than 0.01) and wedged-to-free hepatic vein pressure (r = 0.67, p less than 0.02). Degree of fatty change, fibrosis, inflammation, necrosis and occurrence of Mallory bodies showed no correlation with portal pressure. After morphometrical evaluation of liver biopsies, no significant correlation was found between mean hepatocyte volume or relative sinusoidal vascular volume and portal pressure. To test whether an increase in hepatocyte volume compresses the vascular structures and causes portal hypertension, the ratio of relative sinusoidal vascular volume to mean hepatocyte volume, which expresses the compression of the vascular structures exerted by enlargement of hepatocytes, was related to portal pressure. No significant correlation was found. Further, mean hepatocyte volume was not significantly correlated to relative sinusoidal vascular volume. The present findings are in accordance with the hypothesis that elevated hepatic vascular resistance and portal pressure in alcoholic liver disease are in part determined by the severity of the hepatic architectural destruction and subsequent distorsion and compression of the efferent vein system. Parenchymal changes, including changes in hepatocyte volume, seem to be of minor importance.",

author = "K Krogsgaard and C Gluud and Henriksen, {Jens Henrik Sahl} and P Christoffersen",

note = "Keywords: Adult; Aged; Fatty Liver, Alcoholic; Female; Hepatic Veins; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Middle Aged; Necrosis; Venous Pressure",

year = "1984",

language = "English",

volume = "4",

pages = "699--703",

journal = "Hepatology",

issn = "0270-9139",

publisher = "JohnWiley & Sons, Inc.",

number = "4",

}

TY - JOUR

T1 - Correlation between liver morphology and portal pressure in alcoholic liver disease

AU - Krogsgaard, K

AU - Gluud, C

AU - Henriksen, Jens Henrik Sahl

AU - Christoffersen, P

N1 - Keywords: Adult; Aged; Fatty Liver, Alcoholic; Female; Hepatic Veins; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Middle Aged; Necrosis; Venous Pressure

PY - 1984

Y1 - 1984

N2 - In 14 alcoholic patients, the degree of hepatic architectural destruction was graded (preserved architecture; nodules alternating with preserved architecture; totally destroyed architecture) and related to portal pressure. A positive correlation was found between the degree of architectural destruction and both wedged hepatic vein pressure (r = 0.72, p less than 0.01) and wedged-to-free hepatic vein pressure (r = 0.67, p less than 0.02). Degree of fatty change, fibrosis, inflammation, necrosis and occurrence of Mallory bodies showed no correlation with portal pressure. After morphometrical evaluation of liver biopsies, no significant correlation was found between mean hepatocyte volume or relative sinusoidal vascular volume and portal pressure. To test whether an increase in hepatocyte volume compresses the vascular structures and causes portal hypertension, the ratio of relative sinusoidal vascular volume to mean hepatocyte volume, which expresses the compression of the vascular structures exerted by enlargement of hepatocytes, was related to portal pressure. No significant correlation was found. Further, mean hepatocyte volume was not significantly correlated to relative sinusoidal vascular volume. The present findings are in accordance with the hypothesis that elevated hepatic vascular resistance and portal pressure in alcoholic liver disease are in part determined by the severity of the hepatic architectural destruction and subsequent distorsion and compression of the efferent vein system. Parenchymal changes, including changes in hepatocyte volume, seem to be of minor importance.

AB - In 14 alcoholic patients, the degree of hepatic architectural destruction was graded (preserved architecture; nodules alternating with preserved architecture; totally destroyed architecture) and related to portal pressure. A positive correlation was found between the degree of architectural destruction and both wedged hepatic vein pressure (r = 0.72, p less than 0.01) and wedged-to-free hepatic vein pressure (r = 0.67, p less than 0.02). Degree of fatty change, fibrosis, inflammation, necrosis and occurrence of Mallory bodies showed no correlation with portal pressure. After morphometrical evaluation of liver biopsies, no significant correlation was found between mean hepatocyte volume or relative sinusoidal vascular volume and portal pressure. To test whether an increase in hepatocyte volume compresses the vascular structures and causes portal hypertension, the ratio of relative sinusoidal vascular volume to mean hepatocyte volume, which expresses the compression of the vascular structures exerted by enlargement of hepatocytes, was related to portal pressure. No significant correlation was found. Further, mean hepatocyte volume was not significantly correlated to relative sinusoidal vascular volume. The present findings are in accordance with the hypothesis that elevated hepatic vascular resistance and portal pressure in alcoholic liver disease are in part determined by the severity of the hepatic architectural destruction and subsequent distorsion and compression of the efferent vein system. Parenchymal changes, including changes in hepatocyte volume, seem to be of minor importance.

M3 - Journal article

C2 - 6745860

SN - 0270-9139

VL - 4

SP - 699

EP - 703

JO - Hepatology

JF - Hepatology

IS - 4

ER -