TY - JOUR
T1 - Course of illness in a sample of 265 patients with first-episode psychosis
T2 - five-year follow-up of the Danish OPUS trial
AU - Bertelsen, Mette
AU - Jeppesen, Pia
AU - Petersen, Lone
AU - Thorup, Anne
AU - Øhlenschlaeger, Johan
AU - Le Quach, Phuong
AU - Østergaard Christensen, Torben
AU - Krarup, Gertrud
AU - Jørgensen, Per
AU - Nordentoft, Merete
N1 - Keywords: Adult; Case Management; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Family Therapy; Female; Humans; Longitudinal Studies; Male; Patient Readmission; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Socialization; Substance-Related Disorders; Young Adult
PY - 2009
Y1 - 2009
N2 - There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.
AB - There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.
U2 - 10.1016/j.schres.2008.09.018
DO - 10.1016/j.schres.2008.09.018
M3 - Journal article
SN - 0920-9964
VL - 107
SP - 173
EP - 178
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -