Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Joseph I Ambrus, Jill I Halliday, Nicholas Kanizaj, Nathan Absalom, Kasper Harpsøe, Thomas Balle, Mary Chebib, Malcolm D McLeod

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

11 Citationer (Scopus)

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the a7 nicotinic acetylcholine receptor (nAChR).
OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind48
Udgave nummer53
Sider (fra-til)6699-6701
Antal sider3
ISSN1359-7345
DOI
StatusUdgivet - 7 jul. 2012

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