Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Marco Peluso; Armelle Munnia; Valentina Russo; Andrea Galli; Valeria Pala; Yvonne T. van der Schouw; Matthias B. Schulze; Elisabete Weiderpass; Rosario Tumino; Calogero Saieva; Amiano Exezarreta Pilar; Dagfinn Aune; Alicia K. Heath; Elom Aglago; Antonio Agudo; Salvatore Panico; Kristina Elin Nielsen Petersen; Anne Tjonneland; Lluis Cirera; Miguel Rodriguez-Barranco; Verena Katzke; Rudolf Kaaks; Fulvio Ricceri; Lorenzo Milani; Paolo Vineis; Carlotta Sacerdote

doi:10.3390/nu14122477

Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Marco Peluso^*, Armelle Munnia, Valentina Russo, Andrea Galli, Valeria Pala, Yvonne T. van der Schouw, Matthias B. Schulze, Elisabete Weiderpass, Rosario Tumino, Calogero Saieva, Amiano Exezarreta Pilar, Dagfinn Aune, Alicia K. Heath, Elom Aglago, Antonio Agudo, Salvatore Panico, Kristina Elin Nielsen Petersen, Anne Tjonneland, Lluis Cirera, Miguel Rodriguez-BarrancoVerena Katzke, Rudolf Kaaks, Fulvio Ricceri, Lorenzo Milani, Paolo Vineis, Carlotta Sacerdote

^*Corresponding author af dette arbejde

Afdeling for Miljø og Sundhed

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

14 Downloads (Pure)

Abstract

Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (

Originalsprog	Engelsk
Artikelnummer	2477
Tidsskrift	Nutrients
Vol/bind	14
Udgave nummer	12
Antal sider	13
ISSN	2072-6643
DOI	https://doi.org/10.3390/nu14122477
Status	Udgivet - 2022

Adgang til dokumentet

10.3390/nu14122477Licens: CC BY

FulltextForlagets udgivne version, 322 KBLicens: CC BY

Citationsformater

Peluso, M., Munnia, A., Russo, V., Galli, A., Pala, V., van der Schouw, Y. T., Schulze, M. B., Weiderpass, E., Tumino, R., Saieva, C., Exezarreta Pilar, A., Aune, D., Heath, A. K., Aglago, E., Agudo, A., Panico, S., Petersen, K. E. N., Tjonneland, A., Cirera, L., ... Sacerdote, C. (2022). Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort). Nutrients, 14(12), Artikel 2477. https://doi.org/10.3390/nu14122477

Peluso, M, Munnia, A, Russo, V, Galli, A, Pala, V, van der Schouw, YT, Schulze, MB, Weiderpass, E, Tumino, R, Saieva, C, Exezarreta Pilar, A, Aune, D, Heath, AK, Aglago, E, Agudo, A, Panico, S, Petersen, KEN, Tjonneland, A, Cirera, L, Rodriguez-Barranco, M, Katzke, V, Kaaks, R, Ricceri, F, Milani, L, Vineis, P & Sacerdote, C 2022, 'Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)', Nutrients, bind 14, nr. 12, 2477. https://doi.org/10.3390/nu14122477

@article{1d6bca7696b34a23bb2e743ec4d9b39f,

title = "Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)",

abstract = "Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (",

keywords = "EPIC, diet, cruciferous vegetables, DNA damage, B(a)P-adducts, bulky oxidative lesions, LUNG-CANCER RISK, P-32-POSTLABELING DETECTION, ADDUCT LEVELS, 4-AMINOBIPHENYL-HEMOGLOBIN ADDUCTS, APIACEOUS VEGETABLES, COLORECTAL-CANCER, WESTERN LIGURIA, DIET, NUTRITION, SMOKING",

author = "Marco Peluso and Armelle Munnia and Valentina Russo and Andrea Galli and Valeria Pala and {van der Schouw}, {Yvonne T.} and Schulze, {Matthias B.} and Elisabete Weiderpass and Rosario Tumino and Calogero Saieva and {Exezarreta Pilar}, Amiano and Dagfinn Aune and Heath, {Alicia K.} and Elom Aglago and Antonio Agudo and Salvatore Panico and Petersen, {Kristina Elin Nielsen} and Anne Tjonneland and Lluis Cirera and Miguel Rodriguez-Barranco and Verena Katzke and Rudolf Kaaks and Fulvio Ricceri and Lorenzo Milani and Paolo Vineis and Carlotta Sacerdote",

year = "2022",

doi = "10.3390/nu14122477",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "M D P I AG",

number = "12",

}

TY - JOUR

T1 - Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

AU - Peluso, Marco

AU - Munnia, Armelle

AU - Russo, Valentina

AU - Galli, Andrea

AU - Pala, Valeria

AU - van der Schouw, Yvonne T.

AU - Schulze, Matthias B.

AU - Weiderpass, Elisabete

AU - Tumino, Rosario

AU - Saieva, Calogero

AU - Exezarreta Pilar, Amiano

AU - Aune, Dagfinn

AU - Heath, Alicia K.

AU - Aglago, Elom

AU - Agudo, Antonio

AU - Panico, Salvatore

AU - Petersen, Kristina Elin Nielsen

AU - Tjonneland, Anne

AU - Cirera, Lluis

AU - Rodriguez-Barranco, Miguel

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Ricceri, Fulvio

AU - Milani, Lorenzo

AU - Vineis, Paolo

AU - Sacerdote, Carlotta

PY - 2022

Y1 - 2022

N2 - Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (

AB - Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (

KW - EPIC

KW - diet

KW - cruciferous vegetables

KW - DNA damage

KW - B(a)P-adducts

KW - bulky oxidative lesions

KW - LUNG-CANCER RISK

KW - P-32-POSTLABELING DETECTION

KW - ADDUCT LEVELS

KW - 4-AMINOBIPHENYL-HEMOGLOBIN ADDUCTS

KW - APIACEOUS VEGETABLES

KW - COLORECTAL-CANCER

KW - WESTERN LIGURIA

KW - DIET

KW - NUTRITION

KW - SMOKING

U2 - 10.3390/nu14122477

DO - 10.3390/nu14122477

M3 - Journal article

C2 - 35745207

SN - 2072-6643

VL - 14

JO - Nutrients

JF - Nutrients

IS - 12

M1 - 2477

ER -