Crystallization of Piroxicam Solid Forms and the Effects of Additives

Guangpu Liu, Thomas B. Hansen, Haiyan Qu*, Mingshi Yang, Jari P. Pajander, Jukka Rantanen, Lars P. Christensen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

19 Citationer (Scopus)

Abstract

The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

OriginalsprogEngelsk
TidsskriftChemical Engineering and Technology
Vol/bind37
Udgave nummer8
Sider (fra-til)1297-1304
Antal sider8
ISSN0930-7516
DOI
StatusUdgivet - 2014

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