Cytokines and autoantibodies to cytokines

Klaus Bendtzen*, Morten B. Hansen, Christian Ross, Lars K. Poulsen, Morten Svenson

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

64 Citationer (Scopus)

Abstract

Cytokines are essential components of our defense and repair systems but also potentially harmful mediators of infectious and immunoinflammatory reactions. Clinically important cytokines function systemically as pleiotropic hormones with overlapping effects on many cell types. All engage in a complex network of agonists and antagonists. Some immunoglobulin G (IgG) antibodies have been found to be potent and specific regulators of cytokines. These antibodies bind interleukin (IL‐1)α, IL‐6, IL‐10, leukemia inhibitory factor (LIF), and interferon (IFN)‐α/β with exceptional force. They neutralize their corresponding cytokines ex vivo and perhaps in vivo, although they may also function as cytokine carriers. The biological role of autoantibodies to cytokines is not yet understood, but they may provide a level of regulation not appreciated at present. Inappropriate production/function of such antibodies could be pathogenetically involved in immunoinflammatory and other diseases. Cytokine antibodies may also contribute to the anti‐inflammatory effects of human IgG therapy.

OriginalsprogEngelsk
TidsskriftStem Cells
Vol/bind13
Udgave nummer3
Sider (fra-til)206-222
Antal sider17
ISSN1066-5099
DOI
StatusUdgivet - 1995

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