@article{332817d26da64a5e9f79cc8038ccf7a1,
title = "Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method",
abstract = "Background: Doubly labeled water is gold standard for measuring total energy expenditure (TEE). Measurements using the method are sensitive to the isotope dilution space ratio (DSR). Accuracy and precision of the method might be improved if we could identify factors influencing DSR. Objectives: We evaluated the potential associations of age, sex, ethnicity, anthropometry, body composition, turnover rates of the isotopes, and geographical elevation with DSR. Methods: We used univariate regression analysis to explore the relationships between the continuous variables and analysis of variance to test the relationships between the categorical variables with DSR. Subsequently, we used general linear model (GLM) and 1-way analysis of variance to evaluate the simultaneous associations of age, sex, ethnicity, fat-free mass (FFM) and fat mass (FM) on DSR. Results: From 5678 measurements complied from studies around the world with diverse ethnicity and living at various elevations, the mean DSR was 1.0364 ± 0.0141. No meaningful physiologic effect of any of the continuous and categorical variable on DSR was detected. General linear model analysis revealed no effect of FFM and FM (P > 0.33) on DSR, but DSR decreased with age (P < 0.001) among those aged 60 y and older regardless of sex. Among the Whites who were younger than 60 y, DSR was not related to FFM and FM (P = 0.73) but was affected by both age and sex (P < 0.001). Conclusions: Previous estimates of age-related decline in TEE may have overestimated TEE at age 90 y. Validation studies on older participants are required to confirm this finding.",
keywords = "doubly labeled water, energy expenditure, isotope dilution space ratio",
author = "Wong, {William W.} and Speakman, {John R.} and Ainslie, {Philip N.} and Anderson, {Liam J.} and Leonore Arab and Issad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn VC} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.} and Regina Casper and Close, {Graeme L.} and Colbert, {Lisa H.} and Cooper, {Jamie A.} and Das, {Sai K.} and Davies, {Peter SW} and Simon Eaton and Ulf Ekelund and Catherine Hambly and {El Hamdouchi}, Asmaa and Sonja Entringer and Fudge, {Barry W.} and Melanie Gillingham and Goris, {Annelies H.} and Micheal Gurven and Hoos, {Marije B.} and Sumei Hu and Annemiek Joosen and Katzmarzyk, {Peter T.} and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Larsson, {Christel L.} and Morehen, {James C.} and Morton, {James P.} and Neuhouser, {Marian L.} and Nicklas, {Theresa A.} and Ojiambo, {Robert M.} and Pietilainen, {Kirsi H.} and Pitsiladis, {Yannis P.} and Guy Plasqui and Prentice, {Ross L.} and Roberto Rabinovich and Sj{\"o}din, {Anders M.} and {the IAEA DLW database consortium}",
note = "Funding Information: With support from the USDA/Agricultural Research Service grant 6250-51000-053, the DLW database, is supported by the International Atomic Energy Agency, Taiyo Nippon Sanso, and SERCON. The contents of this publication do not necessarily reflect the views or policies of the USDA nor does mention of trade names, commercial products, or organizations imply endorsement. Funding Information: 1 With support from the USDA/Agricultural Research Service grant 6250-51000-053. The DLW database, is supported by the International Atomic Energy Agency, Taiyo Nippon Sanso and SERCON. The contents of this publication do not necessarily reflect the views or policies of the USDA nor does mention of trade names, commercial products, or organizations imply endorsement. Publisher Copyright: {\textcopyright} 2024 American Society for Nutrition",
year = "2024",
doi = "10.1016/j.tjnut.2024.10.016",
language = "English",
volume = "154",
pages = "3824--3831",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "12",
}