TY - JOUR
T1 - Decreased blood platelet volume and count in patients with liver disease
AU - Jørgensen, B
AU - Fischer, E
AU - Ingeberg, S
AU - Hollaender, N
AU - Ring-Larsen, H
AU - Henriksen, Jens Henrik Sahl
N1 - Keywords: Adult; Aged; Blood Platelets; Blood Volume; Female; Hepatitis, Viral, Human; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Platelet Count
PY - 1984
Y1 - 1984
N2 - Mean platelet volume (MPV) and count (PLT) were assessed in patients with moderately affected liver function. PLT was significantly decreased in patients with liver disease (197 X 10(9)l-1 +/- 87 (SD), no. = 79) compared with that of controls (273 X 10(9)l-1 +/- 53 (SD), no. = 37, P less than 0.001). MPV in patients with liver disease (9.25 +/- 1.14 fl) was significantly lower than that of controls (10.52 +/-0.74 fl, P less than 0.001). In control subjects MPV and PLT were inversely correlated (r = -0.48, P less than 0.01), but statistical significance was not found in patients with liver disease (r = -0.2, 0.05 less than P less than 0.1). It is concluded that the low MPV and PLT are compatible with an intravascular activation (loss of granules) and increased consumption of platelets, which may take place in the diseased liver even in patients with a relatively well preserved liver function.
AB - Mean platelet volume (MPV) and count (PLT) were assessed in patients with moderately affected liver function. PLT was significantly decreased in patients with liver disease (197 X 10(9)l-1 +/- 87 (SD), no. = 79) compared with that of controls (273 X 10(9)l-1 +/- 53 (SD), no. = 37, P less than 0.001). MPV in patients with liver disease (9.25 +/- 1.14 fl) was significantly lower than that of controls (10.52 +/-0.74 fl, P less than 0.001). In control subjects MPV and PLT were inversely correlated (r = -0.48, P less than 0.01), but statistical significance was not found in patients with liver disease (r = -0.2, 0.05 less than P less than 0.1). It is concluded that the low MPV and PLT are compatible with an intravascular activation (loss of granules) and increased consumption of platelets, which may take place in the diseased liver even in patients with a relatively well preserved liver function.
M3 - Journal article
C2 - 6463571
SN - 0036-5521
VL - 19
SP - 492
EP - 496
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 4
ER -